Fexinidazole

157 interactions 12 explained in plain English

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Loperamide Dexamethasone Injection Atenolol Penbutolol Arsenic Trioxide Injection Belumosudil

156 Major 1 Moderate

All (157) Major (156) Moderate (1)

Major

Fexinidazole Lovastatin Altocor® An increased CYP3A4 substrate exposure Details Fexinidazole Lumateperone Caplyta An increased CYP3A4 substrate exposure Details Fexinidazole Lurasidone Latuda An increased CYP3A4 substrate exposure Details Fexinidazole Lurbinectedin Injection Zepzelca An increased CYP3A4 substrate exposure Details Fexinidazole Maraviroc Selzentry An increased CYP3A4 substrate exposure Details Fexinidazole Mefloquine Lariam® An increased risk of QT interval prolongation Details Fexinidazole Metformin Fortamet® Increased metformin exposure Details Fexinidazole Metronidazole Flagyl An increased risk of QT interval prolongation Details Fexinidazole Metronidazole Injection Flagyl An increased risk of QT interval prolongation Details Fexinidazole Metronidazole Topical MetroCream® An increased risk of QT interval prolongation Details Fexinidazole Metronidazole Vaginal MetroGel® Vaginal An increased risk of QT interval prolongation Details Fexinidazole Midazolam Nasal Spray Nayzilam An increased CYP3A4 substrate exposure Details Fexinidazole Midazolam Injection Nayzilam An increased CYP3A4 substrate exposure Details Fexinidazole Moxifloxacin Avelox An increased risk of QT interval prolongation Details Fexinidazole Moxifloxacin Injection Avelox An increased risk of QT interval prolongation Details Fexinidazole Moxifloxacin Ophthalmic Moxeza® An increased risk of QT interval prolongation Details Fexinidazole Nadolol Corgard Increased risk of bradycardia Details Fexinidazole Nafarelin Nasal Spray Synarel An increased risk of QT interval prolongation Details Fexinidazole Nafcillin Injection Unipen® Injection Increased exposure of fexinidazole metabolites with possible increased risk of QT prolongation Details Fexinidazole Naldemedine Symproic An increased CYP3A4 substrate exposure Details Fexinidazole Naloxegol Movantik An increased CYP3A4 substrate exposure Details Fexinidazole Nateglinide Starlix® An increased CYP3A4 substrate exposure Details Fexinidazole Nebivolol Bystolic Increased risk of bradycardia Details Fexinidazole Neratinib Nerlynx An increased CYP3A4 substrate exposure Details Fexinidazole Nevirapine Viramune Increased exposure of fexinidazole metabolites with possible increased risk of QT prolongation Details Fexinidazole Nifedipine Adalat® An increased CYP3A4 substrate exposure Details Fexinidazole Nintedanib Ofev An increased CYP3A4 substrate exposure Details Fexinidazole Nisoldipine Sular An increased CYP3A4 substrate exposure Details Fexinidazole Octreotide Bynfezia An increased risk of QT interval prolongation Details Fexinidazole Octreotide Injection Bynfezia An increased risk of QT interval prolongation Details Fexinidazole Ofloxacin Floxin® An increased risk of QT interval prolongation Details Fexinidazole Ofloxacin Ophthalmic Ocuflox An increased risk of QT interval prolongation Details Fexinidazole Ofloxacin Otic Floxin® Otic An increased risk of QT interval prolongation Details Fexinidazole Olodaterol Oral Inhalation Striverdi An increased risk of QT interval prolongation and an increased risk of ventricular arrhythmias Details Fexinidazole Oxaliplatin Injection Eloxatin® An increased risk of QT interval prolongation Details Fexinidazole Penbutolol Levatol® Increased risk of bradycardia Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.