Flibanserin

54 interactions 4 explained in plain English
Also sold as: Addyi
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Flibanserin Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of respiratory and CNS depression Details Flibanserin Buprenorphine Belbuca Explained An increased risk of respiratory depression and CNS depression Details Flibanserin Relugolix Orgovyx Explained Increased relugolix exposure Details Flibanserin Aripiprazole Injection Abilify Increased risk of CNS depression Details Flibanserin Asciminib Scemblix Increased CYP3A4 exposure and an increased risk of CYP3A4-related adverse reactions Details Flibanserin Asenapine Transdermal Patch Secuado Increased risk of CNS depression Details Flibanserin Betrixaban Bevyxxa® Increased betrixaban exposure and increased risk of bleeding Details Flibanserin Afatinib Gilotrif Increased exposure of afatinib Details Flibanserin Butorphanol Injection Butorphic Increased risk of respiratory and CNS depression Details Flibanserin Butorphanol Nasal Spray Stadol® NS Increased risk of respiratory and CNS depression Details Flibanserin Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Flibanserin Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Flibanserin Cyclosporine Injection Atopica Increased cycloSPORINE exposure Details Flibanserin Cyclosporine Ophthalmic Cequa Increased cycloSPORINE exposure Details Flibanserin Dabigatran Pradaxa® Increased dabigatran exposure and an increased risk of bleeding Details Flibanserin Dabigatran Etexilate Increased dabigatran exposure and an increased risk of bleeding Details Flibanserin Diazepam Nasal Spray Valtoco Increased risk of CNS depression Details Flibanserin Diazepam Rectal Diastat Increased risk of CNS depression Details Flibanserin Digoxin Cardoxin® Increased digoxin exposure and an increased risk of digoxin toxicity Details Flibanserin Diphenhydramine Injection Banophen Increased risk of CNS depression Details Flibanserin Diphenhydramine Topical Afterbite with Antihistamine Increased risk of CNS depression Details Flibanserin Doxorubicin Adriamycin Increased DOXOrubicin exposure and an increased risk of DOXOrubicin-related adverse reactions Details Flibanserin Enasidenib Idhifa Reduced CYP3A substrate exposure and reduced efficacy of CYP3A substrate Details Flibanserin Esketamine Nasal Spray Spravato Increased risk of sedation Details Flibanserin Fentanyl Transdermal Patch Duragesic® Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Flibanserin Finerenone Kerendia Increased finerenone exposure and an increased risk of finerenone-related adverse effects Details Flibanserin Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression Details Flibanserin Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression Details Flibanserin Lacosamide Injection Motpoly An increased risk of CNS depression Details Flibanserin Lanreotide Injection Somatuline Altered exposure to CYP3A4 substrate Details Flibanserin Lefamulin Xenleta Increased lefamulin exposure, an increased risk of lefamulin-related adverse reactions, increased flibanserin exposure and an incr... Details Flibanserin Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Flibanserin Loperamide Diamode An increased loperamide exposure and an increased risk of loperamide-related adverse reactions Details Flibanserin Methylergonovine Methergine Increased methylergonovine exposure Details Flibanserin Metoclopramide Injection Gimoti Increased risk of CNS depression Details Flibanserin Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Flibanserin Midazolam Nasal Spray Nayzilam Increased risk of CNS depression Details

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