Fluocinolone Topical

27 interactions 163 cited references
Also sold as: Capex® Shampoo Derma-Smoothe/FS® Fluocet® Fluonid® Fluotrex® Neo-Synalar® (as a combination product containing Fluocinolone and Neomycin) Synalar Synalar®
About Fluocinolone Topical

Fluocinolone topical is used to treat the itching, redness, dryness, crusting, scaling, inflammation, and discomfort of various skin conditions, including psoriasis (a skin disease in which red, scaly patches form on some areas of the body and eczema (a skin disease that causes the skin to be dry and itchy and to somet… Read the full Fluocinolone Topical drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Fluocinolone Topical Aspirin Acuprin® An increased risk of salicylism subsequent to withdrawal of corticosteroids Details Fluocinolone Topical Bemiparin Increased risk of bleeding Details Fluocinolone Topical Carbamazepine Carbatrol Reduced corticosteroids exposure and reduced efficacy of corticosteroids Details Fluocinolone Topical Cosyntropin False elevations of plasma cortisol levels Details Fluocinolone Topical Ethinyl Estradiol Increased corticosteroid exposure Details Fluocinolone Topical Fosphenytoin Cerebyx Reduced corticosteroid exposure Details Fluocinolone Topical Insulin Aspart, Recombinant Fiasp Reduced blood glucose lowering effect of insulin Details Fluocinolone Topical Insulin Glargine, Recombinant Basaglar Reduced blood glucose lowering effect of insulin Details Fluocinolone Topical Insulin Icodec-Abae Awiqli Reduced efficacy of insulin icodec-abae Details Fluocinolone Topical Macimorelin False-positive or false-negative adult growth hormone deficiency diagnosis Details Fluocinolone Topical Nadroparin Increased risk of bleeding Details Fluocinolone Topical Phenytoin Dilantin Reduced corticosteroid exposure Details Fluocinolone Topical Rabies Vaccine Imovax An inadequate immunological response to the vaccine, an increased risk of altered immunocompetence and reduced immune response to... Details Fluocinolone Topical Relacorilant Lifyorli Reduced relacorilant exposure and reduced efficacy of relacorilant, reduced glucocorticoids exposure and reduced efficacy of gluco... Details Fluocinolone Topical Sargramostim Leukine Increased myeloproliferative effects of sargramostim Details Fluocinolone Topical Somatrogon-Ghla Reduced serum cortisol exposure, an increased risk of central (secondary) hypoadrenalism and attenuated growth-promoting effects o... Details Fluocinolone Topical Upadacitinib Rinvoq Increased risk of gastrointestinal perforations Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.