Flurbiprofen Ophthalmic

263 interactions 378 cited references

Also sold as: Ocufen Ocufen®

About Flurbiprofen Ophthalmic

Flurbiprofen ophthalmic is used to prevent or reduce changes in the eye that may occur during eye surgery. Flurbiprofen ophthalmic is in a class of medications called nonsteroidal anti-inflammatory drugs (NSAIDs). It works by stopping the release of certain natural substances that cause pain and swelling. Read the full Flurbiprofen Ophthalmic drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Xipamide Desirudin Desipramine Deflazacort Danaparoid

1 Contraindicated 208 Major 54 Moderate

All (263) Contraindicated (1) Major (208) Moderate (54)

Contraindicated

Flurbiprofen Ophthalmic Ketorolac Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details

Major

Flurbiprofen Ophthalmic Abciximab An increased risk of bleeding Details Flurbiprofen Ophthalmic Aceclofenac Increased risk of bleeding Details Flurbiprofen Ophthalmic Acemetacin Increased risk of bleeding Details Flurbiprofen Ophthalmic Acenocoumarol An increased risk of bleeding Details Flurbiprofen Ophthalmic Amiloride Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Flurbiprofen Ophthalmic Amineptine An increased risk of bleeding Details Flurbiprofen Ophthalmic Amitriptyline Elavil An increased risk of bleeding Details Flurbiprofen Ophthalmic Amitriptylinoxide An increased risk of bleeding Details Flurbiprofen Ophthalmic Amoxapine An increased risk of bleeding Details Flurbiprofen Ophthalmic Amtolmetin Guacil Increased risk of bleeding Details Flurbiprofen Ophthalmic Anagrelide Agrylin An increased risk of bleeding Details Flurbiprofen Ophthalmic Apalutamide Erleada Reduced CYP2C9 substrates exposure Details Flurbiprofen Ophthalmic Apixaban Eliquis An increased risk of bleeding Details Flurbiprofen Ophthalmic Ardeparin An increased risk of bleeding Details Flurbiprofen Ophthalmic Argatroban An increased risk of bleeding Details Flurbiprofen Ophthalmic Aspirin Acuprin® An increased risk of bleeding, decreased renal function, and an increased risk of gastrointestinal adverse events Details Flurbiprofen Ophthalmic Balsalazide Colazal Increased risk of bleeding Details Flurbiprofen Ophthalmic Bemetizide Reduced diuretic effectiveness and possible nephrotoxicity Details Flurbiprofen Ophthalmic Bemiparin An increased risk of bleeding Details Flurbiprofen Ophthalmic Bendroflumethiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Flurbiprofen Ophthalmic Benzthiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Flurbiprofen Ophthalmic Betrixaban Bevyxxa® An increased risk of bleeding Details Flurbiprofen Ophthalmic Bismuth Subsalicylate Bismarex Increased risk of bleeding Details Flurbiprofen Ophthalmic Bivalirudin Angiomax An increased risk of bleeding Details Flurbiprofen Ophthalmic Bromfenac Bromsite Increased risk of bleeding Details Flurbiprofen Ophthalmic Budesonide Entocort Increased risk of gastrointestinal ulcer or bleeding Details Flurbiprofen Ophthalmic Bufexamac Increased risk of bleeding Details Flurbiprofen Ophthalmic Bumetanide Bumex Reduced diuretic effectiveness and possible nephrotoxicity Details Flurbiprofen Ophthalmic Cangrelor Kengreal An increased risk of bleeding Details Flurbiprofen Ophthalmic Capecitabine Xeloda Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Flurbiprofen Ophthalmic Carbamazepine Carbatrol Reduced CYP2C9 substrate exposure and reduced efficacy of CYP2C9 substrate Details Flurbiprofen Ophthalmic Celecoxib Celebrex An increased risk of GI toxicity and an increased risk of bleeding Details Flurbiprofen Ophthalmic Certoparin An increased risk of bleeding Details Flurbiprofen Ophthalmic Chlorothiazide Diuril Reduced diuretic effectiveness and possible nephrotoxicity Details Flurbiprofen Ophthalmic Chlorthalidone Hemiclor Reduced diuretic effectiveness and possible nephrotoxicity Details Flurbiprofen Ophthalmic Choline Magnesium Trisalicylate Trilisate® Increased risk of bleeding Details Flurbiprofen Ophthalmic Choline Salicylate Increased risk of bleeding Details Flurbiprofen Ophthalmic Cilostazol Pletal® An increased risk of bleeding Details Flurbiprofen Ophthalmic Citalopram Celexa An increased risk of bleeding Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.