Flurbiprofen

299 interactions 378 cited references

Also sold as: Ansaid Ansaid® Lurbipr Lurbiro Ocufen

About Flurbiprofen

Flurbiprofen is an NSAID used to relieve pain, swelling, and stiffness from osteoarthritis and rheumatoid arthritis. Read the full Flurbiprofen drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Injection Ketorolac Ketorolac Ophthalmic Ketorolac Nasal Spray Escitalopram Pemetrexed Injection

4 Contraindicated 235 Major 60 Moderate

All (299) Contraindicated (4) Major (235) Moderate (60)

Major

Flurbiprofen Deutivacaftor Increased CYP2C9 substrate exposure Details Flurbiprofen Dexamethasone Increased risk of gastrointestinal ulcer or bleeding Details Flurbiprofen Dexibuprofen Increased risk of bleeding Details Flurbiprofen Dexketoprofen Increased risk of bleeding Details Flurbiprofen Diazoxide Proglycem Reduced diuretic effectiveness and possible nephrotoxicity Details Flurbiprofen Dibenzepin An increased risk of bleeding Details Flurbiprofen Diclofenac Aleve Arthritis Pain Increased risk of bleeding Details Flurbiprofen Diflunisal Dolobid Increased risk of bleeding Details Flurbiprofen Dipyrone Increased risk of bleeding Details Flurbiprofen Dothiepin An increased risk of bleeding Details Flurbiprofen Doxepin Prudoxin An increased risk of bleeding Details Flurbiprofen Doxifluridine Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Flurbiprofen Droxicam Increased risk of bleeding Details Flurbiprofen Duloxetine An increased risk of bleeding Details Flurbiprofen Eplerenone Inspra Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Flurbiprofen Eptifibatide An increased risk of bleeding Details Flurbiprofen Escitalopram Lexapro An increased risk of bleeding Details Flurbiprofen Ethacrynic Acid Edecrin Reduced diuretic effectiveness and possible nephrotoxicity Details Flurbiprofen Etofenamate Increased risk of bleeding Details Flurbiprofen Etoricoxib Increased risk of bleeding Details Flurbiprofen Etozolin Reduced diuretic effectiveness and possible nephrotoxicity Details Flurbiprofen Felbinac Increased risk of bleeding Details Flurbiprofen Fepradinol Increased risk of bleeding Details Flurbiprofen Feprazone Increased risk of bleeding Details Flurbiprofen Feverfew Increased risk of adverse effects from the nonsteroidal antiinflammatory agent (ie, gastrointestinal, renal effects) Details Flurbiprofen Floctafenine Increased risk of bleeding Details Flurbiprofen Fluconazole Diflucan Increased flurbiprofen exposure and an increased risk of flurbiprofen-related adverse reactions Details Flurbiprofen Flufenamic Acid Increased risk of bleeding Details Flurbiprofen Fluoxetine RECONCILE An increased risk of bleeding Details Flurbiprofen Fluvoxamine An increased risk of bleeding Details Flurbiprofen Fondaparinux Arixtra An increased risk of bleeding Details Flurbiprofen Furosemide Disal Reduced diuretic effectiveness and possible nephrotoxicity Details Flurbiprofen Gossypol Increased risk of adverse gastrointestinal effects Details Flurbiprofen Heparin An increased risk of bleeding Details Flurbiprofen Hydrochlorothiazide Inzirqo Reduced diuretic effectiveness and possible nephrotoxicity Details Flurbiprofen Hydrocortisone Ala-Cort Increased risk of gastrointestinal ulcer or bleeding Details Flurbiprofen Hydroflumethiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Flurbiprofen Ibuprofen Addaprin Increased risk of bleeding Details Flurbiprofen Iloprost Aurlumyn An increased risk of bleeding Details Flurbiprofen Imipramine An increased risk of bleeding Details

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