Flurbiprofen

299 interactions 378 cited references

Also sold as: Ansaid Ansaid® Lurbipr Lurbiro Ocufen

About Flurbiprofen

Flurbiprofen is an NSAID used to relieve pain, swelling, and stiffness from osteoarthritis and rheumatoid arthritis. Read the full Flurbiprofen drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Injection Ketorolac Ketorolac Ophthalmic Ketorolac Nasal Spray Escitalopram Pemetrexed Injection

4 Contraindicated 235 Major 60 Moderate

All (299) Contraindicated (4) Major (235) Moderate (60)

Major

Flurbiprofen Amitriptyline Elavil An increased risk of bleeding Details Flurbiprofen Sertraline An increased risk of bleeding Details Flurbiprofen Apixaban Eliquis An increased risk of bleeding Details Flurbiprofen Aspirin Acuprin® An increased risk of bleeding, decreased renal function, and an increased risk of gastrointestinal adverse events Details Flurbiprofen Aspirin Rectal Aspirin An increased risk of bleeding, decreased renal function, and an increased risk of gastrointestinal adverse events Details Flurbiprofen Betrixaban Bevyxxa® An increased risk of bleeding Details Flurbiprofen Anagrelide Agrylin An increased risk of bleeding Details Flurbiprofen Bromfenac Ophthalmic Bromday® Increased risk of bleeding Details Flurbiprofen Budesonide Entocort Increased risk of gastrointestinal ulcer or bleeding Details Flurbiprofen Budesonide Nasal Spray Rhinocort Increased risk of gastrointestinal ulcer or bleeding Details Flurbiprofen Budesonide Oral Inhalation Pulmicort Increased risk of gastrointestinal ulcer or bleeding Details Flurbiprofen Capecitabine Xeloda Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Flurbiprofen Clopidogrel Plavix An increased risk of bleeding Details Flurbiprofen Cyclosporine Injection Atopica An increased risk of cycloSPORINE nephrotoxicity Details Flurbiprofen Cyclosporine Ophthalmic Cequa An increased risk of cycloSPORINE nephrotoxicity Details Flurbiprofen Dabigatran Pradaxa® An increased risk of bleeding Details Flurbiprofen Dabigatran Etexilate An increased risk of bleeding Details Flurbiprofen Dalteparin Injection Fragmin An increased risk of bleeding Details Flurbiprofen Deflazacort Emflaza Increased risk of gastrointestinal ulcer or bleeding Details Flurbiprofen Dexamethasone Injection Decadron Increased risk of gastrointestinal ulcer or bleeding Details Flurbiprofen Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Increased risk of gastrointestinal ulcer or bleeding Details Flurbiprofen Diclofenac Ophthalmic Voltaren® Eye Drops Increased risk of bleeding Details Flurbiprofen Diclofenac Topical (Actinic Keratosis) Pennsaid Increased risk of bleeding Details Flurbiprofen Diclofenac Topical (Arthritis Pain) Pennsaid® Increased risk of bleeding Details Flurbiprofen Diclofenac Transdermal Patch Flector Increased risk of bleeding Details Flurbiprofen Digoxin Cardoxin® Increased digoxin exposure and prolonged half-life of digoxin Details Flurbiprofen Dipyridamole Permole® An increased risk of bleeding Details Flurbiprofen Edoxaban Savaysa An increased risk of bleeding Details Flurbiprofen Emtricitabine Emtriva Increased emtricitabine exposure and an increased risk of emtricitabine-related adverse effects Details Flurbiprofen Enoxaparin Lovenox An increased risk of bleeding Details Flurbiprofen Enoxaparin Injection Lovenox An increased risk of bleeding Details Flurbiprofen Epoprostenol Flolan An increased risk of bleeding Details Flurbiprofen Etodolac Lodine Increased risk of bleeding Details Flurbiprofen Fenoprofen Fenopron Increased risk of bleeding Details Flurbiprofen Fluorouracil Adrucil Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Flurbiprofen Fluorouracil Injection Adrucil Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Flurbiprofen Fluorouracil Topical Carac Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Flurbiprofen Abciximab An increased risk of bleeding Details Flurbiprofen Aceclofenac Increased risk of bleeding Details Flurbiprofen Acemetacin Increased risk of bleeding Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.