Flurbiprofen

299 interactions 378 cited references

Also sold as: Ansaid Ansaid® Lurbipr Lurbiro Ocufen

About Flurbiprofen

Flurbiprofen is an NSAID used to relieve pain, swelling, and stiffness from osteoarthritis and rheumatoid arthritis. Read the full Flurbiprofen drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Injection Ketorolac Ketorolac Ophthalmic Ketorolac Nasal Spray Escitalopram Pemetrexed Injection

4 Contraindicated 235 Major 60 Moderate

All (299) Contraindicated (4) Major (235) Moderate (60)

Major

Flurbiprofen Pemetrexed Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details Flurbiprofen Pentosan Polysulfate Sodium An increased risk of bleeding Details Flurbiprofen Pentoxifylline Pentoxil® An increased risk of bleeding Details Flurbiprofen Phenindione An increased risk of bleeding Details Flurbiprofen Phenprocoumon An increased risk of bleeding Details Flurbiprofen Phenylbutazone Equi-Phar Increased risk of bleeding Details Flurbiprofen Phenyl Salicylate Increased risk of bleeding Details Flurbiprofen Piketoprofen Increased risk of bleeding Details Flurbiprofen Piretanide Reduced diuretic effectiveness and possible nephrotoxicity Details Flurbiprofen Piroxicam Feldene Increased risk of bleeding Details Flurbiprofen Polythiazide Reduced diuretic effectiveness and possible nephrotoxicity Details Flurbiprofen Potassium Citrate Urocit-K Increased risk of hyperkalemia Details Flurbiprofen Prasugrel Effient An increased risk of bleeding Details Flurbiprofen Prednisolone Flo-Pred® Increased risk of gastrointestinal ulcer or bleeding Details Flurbiprofen Prednisone Deltasone Increased risk of gastrointestinal ulcer or bleeding Details Flurbiprofen Proglumetacin Increased risk of bleeding Details Flurbiprofen Propyphenazone Increased risk of bleeding Details Flurbiprofen Proquazone Increased risk of bleeding Details Flurbiprofen Protein C Ceprotin An increased risk of bleeding Details Flurbiprofen Protriptyline An increased risk of bleeding Details Flurbiprofen Quinethazone Reduced diuretic effectiveness and possible nephrotoxicity Details Flurbiprofen Reviparin An increased risk of bleeding Details Flurbiprofen Rivaroxaban Xarelto An increased risk of bleeding Details Flurbiprofen Rofecoxib Increased risk of bleeding Details Flurbiprofen Salicylamide Increased risk of bleeding Details Flurbiprofen Salicylic Acid Increased risk of bleeding Details Flurbiprofen Salsalate Disalcid Increased risk of bleeding Details Flurbiprofen Selexipag Uptravi An increased risk of bleeding Details Flurbiprofen Sibutramine An increased risk of bleeding Details Flurbiprofen Sodium Salicylate Increased risk of bleeding Details Flurbiprofen Sparsentan Filspari An increased risk of kidney injury, reduced CYP2C9 substrate exposure and reduced CYP2C9 substrate efficacy Details Flurbiprofen Spironolactone Aldactone Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Flurbiprofen Sulfasalazine Azulfidine Increased risk of bleeding Details Flurbiprofen Sulfinpyrazone An increased risk of bleeding Details Flurbiprofen Sulindac Clinoril® Increased risk of bleeding Details Flurbiprofen Sulodexide An increased risk of bleeding Details Flurbiprofen Tacrolimus Astagraf Acute renal failure Details Flurbiprofen Tegafur Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Flurbiprofen Tenofovir Alafenamide Increased tenofovir alafenamide exposure and an increased risk of tenofovir alafenamide-related adverse effects Details Flurbiprofen Tenofovir Disoproxil Fumarate Increased risk of acute renal failure Details

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