Folic Acid

94 interactions 132 cited references
Also sold as: Folacin Folicet® Folvite® Quiofic
About Folic Acid

A B-vitamin used to treat or prevent folic acid deficiency and certain types of anemia caused by low red blood cell count. Read the full Folic Acid drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Capecitabine Pafolacianine Fluorouracil Injection Methotrexate Injection Doxifluridine Fosphenytoin
14 Major 79 Moderate 1 Minor
All (94) Major (14) Moderate (79) Minor (1)

Moderate

Folic Acid Lorazepam Ativan Reduced folic acid exposure and reduced efficacy of folic acid Details Folic Acid Magaldrate Reduced folic acid exposure and reduced efficacy of folic acid Details Folic Acid Magnesium Reduced folic acid exposure and reduced efficacy of folic acid Details Folic Acid Magnesium Carbonate Reduced folic acid exposure and reduced efficacy of folic acid Details Folic Acid Magnesium Hydroxide Almacone® (containing Aluminum Hydroxide, Magnesium Hydroxide, Simethicone) Reduced folic acid exposure and reduced efficacy of folic acid Details Folic Acid Magnesium Oxide Mag-Ox 400 Reduced folic acid exposure and reduced efficacy of folic acid Details Folic Acid Magnesium Peroxide Reduced folic acid exposure and reduced efficacy of folic acid Details Folic Acid Magnesium Trisilicate Reduced folic acid exposure and reduced efficacy of folic acid Details Folic Acid Mephobarbital Reduced folic acid exposure, reduced barbiturates exposure and reduced efficacy of barbiturate Details Folic Acid Methsuximide Celontin Reduced folic acid exposure and reduced efficacy of folic acid Details Folic Acid Midazolam Reduced folic acid exposure and reduced efficacy of folic acid Details Folic Acid Nitrous Oxide Reduced folic acid exposure and reduced efficacy of folic acid Details Folic Acid Nizatidine Axid® Reduced folic acid exposure and reduced efficacy of folic acid Details Folic Acid Oxcarbazepine Oxtellar Reduced folic acid exposure and reduced efficacy of folic acid Details Folic Acid Pentamidine NebuPent Reduced folic acid exposure and reduced efficacy of folic acid Details Folic Acid Pentobarbital Fatal-Plus Reduced folic acid exposure and reduced efficacy of folic acid Details Folic Acid Perampanel FYCOMPA Reduced folic acid exposure and reduced efficacy of folic acid Details Folic Acid Phenobarbital Fidoquel Reduced folic acid exposure, reduced efficacy of folic acid and reduced PHENobarbital or primidone (prodrug of PHENobarbital) expo... Details Folic Acid Pregabalin Bonqat Reduced folic acid exposure and reduced efficacy of folic acid Details Folic Acid Primidone Mysoline Reduced folic acid exposure, reduced efficacy of folic acid and reduced PHENobarbital or primidone (prodrug of PHENobarbital) expo... Details Folic Acid Ranitidine Reduced folic acid exposure and reduced efficacy of folic acid Details Folic Acid Ranitidine Bismuth Citrate Reduced folic acid exposure and reduced efficacy of folic acid Details Folic Acid Roxatidine Reduced folic acid exposure and reduced efficacy of folic acid Details Folic Acid Rufinamide Banzel Reduced folic acid exposure and reduced efficacy of folic acid Details Folic Acid Secobarbital Reduced folic acid exposure, reduced barbiturates exposure and reduced efficacy of barbiturate Details Folic Acid Sodium Bicarbonate Alka-Seltzer® Heartburn Reduced folic acid exposure and reduced efficacy of folic acid Details Folic Acid Stiripentol Diacomit Reduced folic acid exposure and reduced efficacy of folic acid Details Folic Acid Sulfasalazine Azulfidine Reduced folic acid exposure and reduced efficacy of folic acid Details Folic Acid Tea Decreased folic acid exposure Details Folic Acid Tetracycline Achromycin V® Reduced tetracycline exposure and reduced efficacy of tetracycline Details Folic Acid Tiagabine Gabitril Reduced folic acid exposure and reduced efficacy of folic acid Details Folic Acid Topiramate Eprontia Reduced folic acid exposure and reduced efficacy of folic acid Details Folic Acid Valproic Acid Depakene® Reduced folic acid exposure and reduced efficacy of folic acid Details Folic Acid Vigabatrin Sabril Reduced folic acid exposure and reduced efficacy of folic acid Details Folic Acid Zonisamide Zonegran Reduced folic acid exposure and reduced efficacy of folic acid Details Folic Acid Lacosamide Injection Motpoly Reduced folic acid exposure and reduced efficacy of folic acid Details Folic Acid Levetiracetam Injection Elepsia Reduced folic acid exposure and reduced efficacy of folic acid Details Folic Acid Midazolam Nasal Spray Nayzilam Reduced folic acid exposure and reduced efficacy of folic acid Details Folic Acid Midazolam Injection Nayzilam Reduced folic acid exposure and reduced efficacy of folic acid Details

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