Folic Acid

94 interactions 132 cited references
Also sold as: Folacin Folicet® Folvite® Quiofic
About Folic Acid

A B-vitamin used to treat or prevent folic acid deficiency and certain types of anemia caused by low red blood cell count. Read the full Folic Acid drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Capecitabine Pafolacianine Fluorouracil Injection Methotrexate Injection Doxifluridine Fosphenytoin
14 Major 79 Moderate 1 Minor
All (94) Major (14) Moderate (79) Minor (1)

Major

Folic Acid Capecitabine Xeloda Increased capecitabine or doxifluridine or fluorouracil (prodrugs of capecitabine) or tegafur (prodrug of fluorouracil) exposure a... Details Folic Acid Fluorouracil Adrucil Increased capecitabine or doxifluridine or fluorouracil (prodrugs of capecitabine) or tegafur (prodrug of fluorouracil) exposure a... Details Folic Acid Fluorouracil Injection Adrucil Increased capecitabine or doxifluridine or fluorouracil (prodrugs of capecitabine) or tegafur (prodrug of fluorouracil) exposure a... Details Folic Acid Fluorouracil Topical Carac Increased capecitabine or doxifluridine or fluorouracil (prodrugs of capecitabine) or tegafur (prodrug of fluorouracil) exposure a... Details Folic Acid Doxifluridine Increased capecitabine or doxifluridine or fluorouracil (prodrugs of capecitabine) or tegafur (prodrug of fluorouracil) exposure a... Details Folic Acid Fosphenytoin Cerebyx Reduced folic acid exposure and reduce phenytoin or fosphenytoin (prodrug of phenytoin) exposure Details Folic Acid Methotrexate Jylamvo Reduced folic acid exposure, reduced methotrexate exposure and reduced efficacy of methotrexate Details Folic Acid Pafolacianine Reduced detection of malignant lesions Details Folic Acid Phenytoin Dilantin Reduced folic acid exposure and reduce phenytoin or fosphenytoin (prodrug of phenytoin) exposure Details Folic Acid Pyrimethamine Reduced efficacy of folic acid Details Folic Acid Tegafur Increased capecitabine or doxifluridine or fluorouracil (prodrugs of capecitabine) or tegafur (prodrug of fluorouracil) exposure a... Details Folic Acid Triamterene Dyrenium Reduced folic acid exposure Details Folic Acid Trimethoprim Primsol Reduced folic acid exposure Details Folic Acid Methotrexate Injection Abitrexate® Reduced folic acid exposure, reduced methotrexate exposure and reduced efficacy of methotrexate Details

Moderate

Folic Acid Acetazolamide Diamox® Sequels® Reduced folic acid exposure and reduced efficacy of folic acid Details Folic Acid Brivaracetam Briviact Reduced folic acid exposure and reduced efficacy of folic acid Details Folic Acid Brivaracetam Injection Briviact Reduced folic acid exposure and reduced efficacy of folic acid Details Folic Acid Cholestyramine Resin Locholest® Reduced folic acid exposure and reduced efficacy of folic acid Details Folic Acid Colestipol Colestid Reduced folic acid exposure and reduced efficacy of folic acid Details Folic Acid Diazepam Nasal Spray Valtoco Reduced folic acid exposure and reduced efficacy of folic acid Details Folic Acid Diazepam Rectal Diastat Reduced folic acid exposure and reduced efficacy of folic acid Details Folic Acid Ethosuximide Zarontin Reduced folic acid exposure and reduced efficacy of folic acid Details Folic Acid Famotidine Calmicid Reduced folic acid exposure and reduced efficacy of folic acid Details Folic Acid Famotidine Injection Calmicid Reduced folic acid exposure and reduced efficacy of folic acid Details Folic Acid Felbamate Felbatol Reduced folic acid exposure and reduced efficacy of folic acid Details Folic Acid Aluminum Carbonate, Basic Reduced folic acid exposure and reduced efficacy of folic acid Details Folic Acid Aluminum Hydroxide AlternaGEL® Reduced folic acid exposure and reduced efficacy of folic acid Details Folic Acid Aluminum Phosphate Reduced folic acid exposure and reduced efficacy of folic acid Details Folic Acid Amobarbital Amytal Reduced folic acid exposure, reduced barbiturates exposure and reduced efficacy of barbiturate Details Folic Acid Barbital Reduced folic acid exposure, reduced barbiturates exposure and reduced efficacy of barbiturate Details Folic Acid Butabarbital Reduced folic acid exposure, reduced barbiturates exposure and reduced efficacy of barbiturate Details Folic Acid Calcium Carbonate Alka-Mints Reduced folic acid exposure and reduced efficacy of folic acid Details Folic Acid Calcium Silicate Reduced folic acid exposure and reduced efficacy of folic acid Details Folic Acid Cannabidiol Epidiolex Reduced folic acid exposure and reduced efficacy of folic acid Details Folic Acid Carbamazepine Carbatrol Reduced folic acid exposure and reduced efficacy of folic acid Details Folic Acid Cenobamate Xcopri Reduced folic acid exposure and reduced efficacy of folic acid Details Folic Acid Cholestyramine Prevalite Reduced folic acid exposure and reduced efficacy of folic acid Details Folic Acid Cimetidine Tagamet Reduced folic acid exposure and reduced efficacy of folic acid Details Folic Acid Clobazam Onfi Reduced folic acid exposure and reduced efficacy of folic acid Details Folic Acid Clonazepam Klonopin Reduced folic acid exposure and reduced efficacy of folic acid Details

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