Fosaprepitant

55 interactions 4 explained in plain English
Also sold as: Emend Injection Focinvez
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Fosaprepitant Acetaminophen And Codeine Capital® & Codeine Explained Increased codeine and morphine exposure Details Fosaprepitant Buprenorphine Belbuca Explained Increased buprenorphine exposure and an increased risk of buprenorphine-related adverse events Details Fosaprepitant Colchicine Colcrys Explained Increased colchicine exposure and an increased risk of colchicine-related toxicity Details Fosaprepitant Bedaquiline Sirturo Increased bedaquiline exposure Details Fosaprepitant Budesonide Entocort Increased budesonide exposure Details Fosaprepitant Budesonide Nasal Spray Rhinocort Increased budesonide exposure Details Fosaprepitant Budesonide Oral Inhalation Pulmicort Increased budesonide exposure Details Fosaprepitant Cobimetinib Cotellic Increased cobimetinib plasma concentrations Details Fosaprepitant Cyclosporine Injection Atopica Increased cycloSPORINE exposure Details Fosaprepitant Cyclosporine Ophthalmic Cequa Increased cycloSPORINE exposure Details Fosaprepitant Diazepam Nasal Spray Valtoco Increased exposure to benzodiazepines and an increased risk of benzodiazepine-related adverse reactions Details Fosaprepitant Diazepam Rectal Diastat Increased exposure to benzodiazepines and an increased risk of benzodiazepine-related adverse reactions Details Fosaprepitant Docetaxel Beizray Increased chemotherapeutic agent exposure Details Fosaprepitant Docetaxel Injection Beizray Increased chemotherapeutic agent exposure Details Fosaprepitant Doxorubicin Adriamycin Increased doxorubicin exposure and an increased risk of doxorubicin-related adverse reactions Details Fosaprepitant Encorafenib Braftovi Reduced CYP3A4 substrate exposure and reduced efficacy of CYP3A4 substrate Details Fosaprepitant Estradiol Delestrogen Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and an increased risk of breakthrough bleedin... Details Fosaprepitant Estradiol Topical Divigel Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and an increased risk of breakthrough bleedin... Details Fosaprepitant Estradiol Transdermal Patch Alora® Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and an increased risk of breakthrough bleedin... Details Fosaprepitant Fentanyl Transdermal Patch Duragesic® Increased fentaNYL exposure and an increased risk of prolonged opioid effects Details Fosaprepitant Finerenone Kerendia Increased finerenone exposure and an increased risk of finerenone-related adverse effects Details Fosaprepitant Ifosfamide Injection Ifex Increased chemotherapeutic agent exposure Details Fosaprepitant Ivabradine Corlanor Increased exposure of ivabradine Details Fosaprepitant Ketoconazole Topical Extina® Foam Increased aprepitant or fosaprepitant (prodrug of aprepitant) exposure Details Fosaprepitant Lefamulin Xenleta Increased sensitive CYP3A4 substrate exposure and an increased risk of sensitive CYP3A4 substrate-related toxicities associated wi... Details Fosaprepitant Lenacapavir Injection Sunlenca Increased sensitive CYP3A substrate exposure and an increased risk of sensitive CYP3A substrate-mediated adverse reactions Details Fosaprepitant Lenacapavir Oral Sunlenca Increased sensitive CYP3A substrate exposure and an increased risk of sensitive CYP3A substrate-mediated adverse reactions Details Fosaprepitant Letermovir Injection Prevymis Increased aprepitant exposure Details Fosaprepitant Levonorgestrel After banger Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and an increased risk of breakthrough bleedin... Details Fosaprepitant Levonorgestrel Intrauterine System Kyleena Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and an increased risk of breakthrough bleedin... Details Fosaprepitant Loperamide Diamode Increased loperamide exposure and an increased risk of loperamide-related adverse reactions Details Fosaprepitant Lurasidone Latuda Increased lurasidone exposure Details Fosaprepitant Medroxyprogesterone Amen® Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and an increased risk of breakthrough bleedin... Details Fosaprepitant Medroxyprogesterone Injection Depo-Provera Reduced hormonal contraceptive exposure, reduced efficacy of hormonal contraceptives and an increased risk of breakthrough bleedin... Details Fosaprepitant Methylergonovine Methergine Increased methylergonovine exposure Details Fosaprepitant Mitapivat Aqvesme Reduced CYP3A substrate exposure Details Fosaprepitant Naloxegol Movantik Increased naloxegol exposure Details Fosaprepitant Nifedipine Adalat® Increased NIFEdipine exposure Details Fosaprepitant Olaparib Lynparza Increased olaparib exposure Details Fosaprepitant Olutasidenib Rezlidhia Reduced sensitive CYP3A substrate exposure Details

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