Furosemide Injection and Bepridil: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Furosemide Injection
Bepridil
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Hypokalemia and subsequent cardiotoxicity (torsades de pointes)
Interaction Deep Dive
Most cases of torsades de pointes associated with bepridil have developed in patients with hypokalemia usually related to diuretic use23. If patients receiving bepridil require diuretic therapy, a potassium-sparing diuretic should be used to avoid hypokalemia. Combination diuretics (a thiazide and potassium-sparing diuretic, for example) can be administered concurrently with bepridil 4.
Why it happens (mechanism)
Diuretic induced hypokalemia
Literature reports
1 report — tap to read
a) The in vitro combination of furosemide and bepridil in human plasma does not affect the protein binding of bepridil 1.
Common questions
Can I take Furosemide Injection and Bepridil together?
Hypokalemia and subsequent cardiotoxicity (torsades de pointes) Always confirm with your pharmacist or prescriber before making any change.
How serious is the Furosemide Injection and Bepridil interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "delayed". Effects tend to build up gradually over days to weeks.
How strong is the evidence for this interaction?
The evidence is graded "probable". Good supporting evidence, though not definitively proven.
Questions for your pharmacist
- Does my dose of Furosemide Injection or Bepridil need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (4)
- Pritchard JF, McKown LA, Dvorchik BH, et al: Plasma protein binding of bepridil. J Clin Pharmacol 1985; 25:347-353. DOI
- Manouvrier J, Sagot M, Caron C, et al: Nine cases of torsade de pointes with bepridil administration. Am Heart J 1986; 111:1005-1007. PubMed
- Product Information: Vascor(R), bepridil. McNeil Pharmaceutical, Spring House, PA, 1995.
- Hollingshead LM, Faulds D, & Fitton A: Bepridil. A review of its pharmacological properties and therapeutic use in stable angina pectoris. Drugs 1992; 44:835-857.
Keep reading about Furosemide Injection
Keep reading about Bepridil
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