Furosemide

Name: Furosemide Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

105 interactions 5 explained in plain English

Also sold as: Disal Furoscix Lasix Salix - substance

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Desmopressin Nasal Cefotetan Injection Diclofenac Topical (Arthritis Pain) Ketorolac Meloxicam Perindopril

1 Contraindicated 88 Major 15 Moderate 1 Minor

All (105) Contraindicated (1) Major (88) Moderate (15) Minor (1)

Major

Furosemide Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related toxicity, altered (increased/reduced) furosemide exposu... Details Furosemide Miglitol Glyset® An increased risk of hyperglycemia and an increased insulin requirement Details Furosemide Moexipril Univasc® An increased risk of severe hypotension and deterioration in renal function, including renal failure Details Furosemide Morphine Injection Astramorph® PF Reduced efficacy of diuretics Details Furosemide Nabumetone Relafen Reduced diuretic effectiveness and possible nephrotoxicity Details Furosemide Naproxen Aleve Reduced diuretic effectiveness and possible nephrotoxicity Details Furosemide Nateglinide Starlix® An increased risk of hyperglycemia and an increased insulin requirement Details Furosemide Perindopril Aceon An increased risk of severe hypotension and deterioration in renal function, including renal failure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.