Ganciclovir

17 interactions 270 cited references
Also sold as: Cytovene® Oral Zirgan
About Ganciclovir

Ganciclovir capsules are used to treat cytomegalovirus (CMV) retinitis (eye infection that can cause blindness) in people whose immune system is not working normally. Ganciclovir capsules are used to treat CMV retinitis after the condition has been controlled by intravenous (injected into a vein) ganciclovir. Ganciclov… Read the full Ganciclovir drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Tenofovir Alafenamide Mercaptopurine Methotrexate Mycophenolate Mofetil Maribavir Tramadol
14 Major 3 Moderate
All (17) Major (14) Moderate (3)

Major

Ganciclovir Azathioprine Azasan An increased risk of hepatotoxicity Details Ganciclovir Emtricitabine Emtriva Increased emtricitabine exposure and an increased risk of emtricitabine-related adverse effects Details Ganciclovir Bupropion Aplenzin Increased risk of seizures Details Ganciclovir Clomipramine Anafranil Increased risk of seizures Details Ganciclovir Hydroxychloroquine Plaquenil An increased risk of seizures Details Ganciclovir Imipenem CNS toxicity (seizures) Details Ganciclovir Levoketoconazole Recorlev Increased risk of serious hepatotoxicity and drug-induced liver injury Details Ganciclovir Maribavir Livtencity Reduced ganciclovir or valGANciclovir exposure and reduced efficacy of ganciclovir or valGANciclovir Details Ganciclovir Mercaptopurine Purinethol® An increased risk of hepatotoxicity Details Ganciclovir Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Ganciclovir Mycophenolate Mofetil Increased ganciclovir exposure and an increased risk of ganciclovir-related adverse reactions Details Ganciclovir Tenofovir Alafenamide Increased tenofovir alafenamide exposure and an increased risk of tenofovir alafenamide-related adverse effects Details Ganciclovir Tramadol ConZip An increased risk of seizure Details Ganciclovir Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details

Moderate

Ganciclovir Didanosine Videx® An increased risk of didanosine toxicity (neuropathy, diarrhea, pancreatitis) Details Ganciclovir Probenecid Increased risk for ganciclovir toxicity Details Ganciclovir Tacrolimus Astagraf An increased risk of nephrotoxicity Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.