Ganciclovir Ophthalmic

16 interactions 270 cited references
Also sold as: Zirgan Zirgan®
About Ganciclovir Ophthalmic

Ganciclovir ophthalmic is used to treat herpetic keratitis (dendritic ulcers; eye ulcers caused by a herpes simplex virus infection). Ganciclovir is in a class of medications called antivirals. It works by stopping the spread of the herpes virus in the eye. Read the full Ganciclovir Ophthalmic drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Azathioprine Bupropion Clomipramine Emtricitabine Hydroxychloroquine Imipenem
13 Major 3 Moderate
All (16) Major (13) Moderate (3)

Major

Ganciclovir Ophthalmic Azathioprine Azasan An increased risk of hepatotoxicity Details Ganciclovir Ophthalmic Bupropion Aplenzin Increased risk of seizures Details Ganciclovir Ophthalmic Clomipramine Anafranil Increased risk of seizures Details Ganciclovir Ophthalmic Emtricitabine Emtriva Increased emtricitabine exposure and an increased risk of emtricitabine-related adverse effects Details Ganciclovir Ophthalmic Hydroxychloroquine Plaquenil An increased risk of seizures Details Ganciclovir Ophthalmic Imipenem CNS toxicity (seizures) Details Ganciclovir Ophthalmic Levoketoconazole Recorlev Increased risk of serious hepatotoxicity and drug-induced liver injury Details Ganciclovir Ophthalmic Maribavir Livtencity Reduced ganciclovir or valGANciclovir exposure and reduced efficacy of ganciclovir or valGANciclovir Details Ganciclovir Ophthalmic Mercaptopurine Purinethol® An increased risk of hepatotoxicity Details Ganciclovir Ophthalmic Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Ganciclovir Ophthalmic Mycophenolate Mofetil Increased ganciclovir exposure and an increased risk of ganciclovir-related adverse reactions Details Ganciclovir Ophthalmic Tenofovir Alafenamide Increased tenofovir alafenamide exposure and an increased risk of tenofovir alafenamide-related adverse effects Details Ganciclovir Ophthalmic Tramadol ConZip An increased risk of seizure Details

Moderate

Ganciclovir Ophthalmic Didanosine Videx® An increased risk of didanosine toxicity (neuropathy, diarrhea, pancreatitis) Details Ganciclovir Ophthalmic Probenecid Increased risk for ganciclovir toxicity Details Ganciclovir Ophthalmic Tacrolimus Astagraf An increased risk of nephrotoxicity Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.