Gentamicin Injection and Letibotulinumtoxina-Wlbg: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Gentamicin Injection
Letibotulinumtoxina-Wlbg
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased neuromuscular weakness
Interaction Deep Dive
Concomitant use of letibotulinumtoxinA-wlbg and aminoglycosides may potentiate the effects of letibotulinumtoxinA-wlbg which may result in excessive neuromuscular weakness due to interference with neuromuscular transmission by aminoglycosides. Use caution with concurrent use of letibotulinumtoxinA-wlbg and aminoglycosides, and monitor closely for excessive neuromuscular weakness1.
Why it happens (mechanism)
Interference with neuromuscular transmission
Common questions
Can I take Gentamicin Injection and Letibotulinumtoxina-Wlbg together?
Increased neuromuscular weakness Always confirm with your pharmacist or prescriber before making any change.
How serious is the Gentamicin Injection and Letibotulinumtoxina-Wlbg interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Gentamicin Injection or Letibotulinumtoxina-Wlbg need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: LETYBO intramuscular injection, letibotulinumtoxinA-wlbg intramuscular injection. Hugel America, Inc. (Per Manufacturer), Newport Beach, CA, 2024.
Keep reading about Gentamicin Injection
Keep reading about Letibotulinumtoxina-Wlbg
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Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
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