Gentamicin Topical and Ataluren: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Gentamicin Topical
Ataluren
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Decreased ataluren activity and increased risk of aminoglycoside-associated nephrotoxicity
Interaction Deep Dive
The concomitant use of ataluren with IV aminoglycosides is contraindicated, as concurrent use may reduce the efficacy of ataluren and increase the nephrotoxic effects of IV aminoglycosides. If treatment with an IV aminoglycoside is clinically required, interrupt ataluren during aminoglycoside administration. Ataluren may be restarted 2 days after the IV aminoglycoside is discontinued. Carefully monitor renal function1.
Why it happens (mechanism)
Decreased ataluren readthrough activity; unknown
Literature reports
1 report — tap to read
a) In a clinical trial, serum creatinine elevations occurred with coadministration of ataluren, IV aminoglycosides, and other antibiotics in several patients with nonsense mutation-associated cystic fibrosis. Serum creatinine elevations resolved in all cases with IV aminoglycoside discontinuation and either ataluren continuation or interruption 2.
Common questions
Can I take Gentamicin Topical and Ataluren together?
Decreased ataluren activity and increased risk of aminoglycoside-associated nephrotoxicity Always confirm with your pharmacist or prescriber before making any change.
How serious is the Gentamicin Topical and Ataluren interaction?
It is rated contraindicated. These should generally not be used together.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "probable". Good supporting evidence, though not definitively proven.
Questions for your pharmacist
- Does my dose of Gentamicin Topical or Ataluren need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (2)
- Product Information: Translarna oral granules for suspension, ataluren oral granules for suspension. PTC Therapeutics International Limited (per EMA), Dublin, Ireland, 2017.
- Product Information: Translarna oral suspension, ataluren oral suspension. PTC Therapeutics, Limited (per EMA), Uxbridge, United Kingdom, 2014.
Keep reading about Gentamicin Topical
Keep reading about Ataluren
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