Gentamicin Topical

75 interactions 599 cited references

Also sold as: Garamycin®

About Gentamicin Topical

Topical gentamicin is used in adults and children 1 year of age and older to treat skin infections caused by certain bacteria. Topical gentamicin is in a class of medications called antibiotics. It works by killing bacteria that cause infections. Read the full Gentamicin Topical drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ataluren Agalsidase Alfa Alcuronium Aspirin Atracurium Bumetanide

1 Contraindicated 36 Major 12 Moderate 26 Minor

All (75) Contraindicated (1) Major (36) Moderate (12) Minor (26)

Contraindicated

Gentamicin Topical Ataluren Decreased ataluren activity and increased risk of aminoglycoside-associated nephrotoxicity Details

Major

Gentamicin Topical Agalsidase Alfa Decreased efficacy of agalsidase alfa Details Gentamicin Topical Alcuronium Enhanced and/or prolonged neuromuscular blockade which may lead to respiratory depression and paralysis Details Gentamicin Topical Aspirin Acuprin® Increased aspirin exposure and an increased risk of nephrotoxicity Details Gentamicin Topical Atracurium Enhanced and/or prolonged neuromuscular blockade which may lead to respiratory depression and paralysis Details Gentamicin Topical Bumetanide Bumex An increased risk of ototoxicity Details Gentamicin Topical Cefepime An increased risk of nephrotoxicity and an increased risk of ototoxicity Details Gentamicin Topical Cholera Vaccine, Live Reduced immune response to the cholera vaccine Details Gentamicin Topical Cidofovir Nephrotoxicity Details Gentamicin Topical Cisatracurium Enhanced and/or prolonged neuromuscular blockade which may lead to respiratory depression and paralysis Details Gentamicin Topical Colistimethate Sodium Respiratory depression Details Gentamicin Topical Cyclosporine Atopica An increased risk of nephrotoxicity and increased risk of renal dysfunction Details Gentamicin Topical Decamethonium Enhanced and/or prolonged neuromuscular blockade which may lead to respiratory depression and paralysis Details Gentamicin Topical Digoxin Cardoxin® Increased digoxin exposure Details Gentamicin Topical Doxacurium Enhanced and/or prolonged neuromuscular blockade which may lead to respiratory depression and paralysis Details Gentamicin Topical Emtricitabine Emtriva Increased emtricitabine exposure and an increased risk of emtricitabine-related adverse effects Details Gentamicin Topical Ethacrynic Acid Edecrin Increased gentamicin plasma and tissue concentrations and additive ototoxicity Details Gentamicin Topical Fazadinium Enhanced and/or prolonged neuromuscular blockade which may lead to respiratory depression and paralysis Details Gentamicin Topical Foscarnet Foscavir Nephrotoxicity Details Gentamicin Topical Furosemide Disal Increased gentamicin plasma and tissue concentrations and additive ototoxicity and/or nephrotoxicity Details Gentamicin Topical Gallamine Enhanced and/or prolonged neuromuscular blockade which may lead to respiratory depression and paralysis Details Gentamicin Topical Hexafluorenium Enhanced and/or prolonged neuromuscular blockade which may lead to respiratory depression and paralysis Details Gentamicin Topical Letibotulinumtoxina-Wlbg Letybo Increased neuromuscular weakness Details Gentamicin Topical Lysine Increased risk of nephrotoxicity Details Gentamicin Topical Metocurine Enhanced and/or prolonged neuromuscular blockade which may lead to respiratory depression and paralysis Details Gentamicin Topical Mivacurium Enhanced and/or prolonged neuromuscular blockade which may lead to respiratory depression and paralysis Details Gentamicin Topical Pancuronium Enhanced and/or prolonged neuromuscular blockade which may lead to respiratory depression and paralysis Details Gentamicin Topical Pipecuronium Enhanced and/or prolonged neuromuscular blockade which may lead to respiratory depression and paralysis Details Gentamicin Topical Rapacuronium Enhanced and/or prolonged neuromuscular blockade which may lead to respiratory depression and paralysis Details Gentamicin Topical Rocuronium Enhanced and/or prolonged neuromuscular blockade which may lead to respiratory depression and paralysis Details Gentamicin Topical Succinylcholine Anectine Enhanced neuromuscular blockade Details Gentamicin Topical Tacrolimus Astagraf An increased risk of nephrotoxicity Details Gentamicin Topical Teicoplanin Increased risk of nephrotoxicity and/or ototoxicity Details Gentamicin Topical Tenofovir Alafenamide Increased tenofovir alafenamide exposure and an increased risk of tenofovir alafenamide-related adverse effects Details Gentamicin Topical Tubocurarine Enhanced and/or prolonged neuromuscular blockade which may lead to respiratory depression and paralysis Details Gentamicin Topical Vancomycin Firvanq An increased risk of ototoxicity and an increased risk if nephrotoxicity Details Gentamicin Topical Vecuronium Enhanced and/or prolonged neuromuscular blockade which may lead to respiratory depression and paralysis Details

Moderate

Gentamicin Topical Capreomycin Gentamicin toxicity (ototoxicity, nephrotoxicity) Details Gentamicin Topical Carboplatin Kyxata Ototoxicity Details Gentamicin Topical Hydrochlorothiazide Inzirqo An increased risk of worsening of renal function Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.