Glecaprevir and Atorvastatin: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Jul 15, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Atorvastatin
Glecaprevir
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased atorvastatin exposure and an increased risk of myopathy and rhabdomyolysis
Interaction Deep Dive
Avoid concurrent use of atorvastatin with glecaprevir/pibrentasvir, as it may result in increased atorvastatin exposure, thereby increasing the risk of myopathy, including rhabdomyolysis31. If coadministration cannot be avoided, monitor for signs and symptoms of myopathy particularly during initiation of therapy and during upward dose titration of either drug 21.
Why it happens (mechanism)
Inhibition of BCRP-mediated metabolism of atorvastatin; inhibition of OATP1B1-mediated efflux transport of atorvastatin; inhibition of OATP1B3-mediated efflux transport of atorvastatin; inhibition of P-gp-mediated efflux transport of atorvastatin; inhibition of CYP3A-mediated metabolism of atorvastatin
Literature reports
2 reports — tap to read
a) Coadministration of glecaprevir 400 mg/pibrentasvir 120 mg once daily with atorvastatin 10 mg once daily for 7 days increased the atorvastatin AUC by 8.28-fold and Cmax by 22-fold compared with atorvastatin alone 21.
b) In a pharmacokinetic study (N=11), when atorvastatin 10 mg once daily was coadministered with glecaprevir 400 mg/pibrentasvir 120 mg once daily, atorvastatin Cmax increased by 2100% and AUC increased by 728% 3.
Common questions
Can I take Glecaprevir and Atorvastatin together?
Increased atorvastatin exposure and an increased risk of myopathy and rhabdomyolysis Always confirm with your pharmacist or prescriber before making any change.
How serious is the Glecaprevir and Atorvastatin interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "established". Well documented — supported by controlled studies or strong clinical data.
From our Q&A
Real reader questions about these medications, each personally answered by our pharmacist:
Questions for your pharmacist
- Does my dose of Glecaprevir or Atorvastatin need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (3)
- Product Information: ATORVALIQ(R) oral suspension, atorvastatin calcium oral suspension. CMP Pharma Inc (per FDA), Farmville, NC, 2023. DailyMed
- Product Information: LIPITOR(R) oral tablets, atorvastatin calcium oral tablets. Viatris Specialty LLC (per FDA), Morgantown, WV, 2022. DailyMed
- Product Information: MAVYRET(R) oral tablets, oral pellets, glecaprevir pibrentasvir oral tablets, oral pellets. AbbVie Inc (per FDA), North Chicago, IL, 2023. DailyMed
Keep reading about Atorvastatin
Keep reading about Glecaprevir
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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