Glipizide

197 interactions 436 cited references

Also sold as: Glucotrol Glucotrol® Glucotrol® XL

About Glipizide

Glipizide is a sulfonylurea that lowers blood sugar in people with type 2 diabetes by stimulating the pancreas to produce insulin. Read the full Glipizide drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Insulin Aspart, Recombinant Hydrochlorothiazide Hydroxychloroquine Hydroflumethiazide Insulin Indapamide

87 Major 101 Moderate 9 Minor

All (197) Major (87) Moderate (101) Minor (9)

Major

Glipizide Acarbose Prandase® An increased risk of hypoglycemia Details Glipizide Abiraterone Abirtega An increased risk of severe hypoglycemia Details Glipizide Capecitabine Xeloda Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Glipizide Chloroquine Aralen® Hypoglycemia Details Glipizide Delafloxacin Baxdela Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Glipizide Delafloxacin Injection Baxdela Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Glipizide Disopyramide Norpace Increased risk of hypoglycemia Details Glipizide Dulaglutide Injection Trulicity Increased risk of hypoglycemia Details Glipizide Entacapone Comtan Increased exposure of CYP2C9 substrate Details Glipizide Fluorouracil Adrucil Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Glipizide Fluorouracil Injection Adrucil Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Glipizide Fluorouracil Topical Carac Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Glipizide Furosemide Injection Disal An increased risk of hyperglycemia and an increased insulin requirement Details Glipizide Gatifloxacin Ophthalmic Zymar® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Glipizide Gemifloxacin Factive Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Glipizide Abiraterone Acetate Abirtega An increased risk of severe hypoglycemia Details Glipizide Abiraterone Acetate, Micronized Abirtega An increased risk of severe hypoglycemia Details Glipizide Acoramidis Increased sensitive CYP2C9 substrate exposure and an increased risk of sensitive CYP2C9 substrate toxicity Details Glipizide Apalutamide Erleada Reduced CYP2C9 substrates exposure Details Glipizide Carbamazepine Carbatrol Reduced CYP2C9 substrate exposure and reduced efficacy of CYP2C9 substrate Details Glipizide Ceritinib Zykadia Increased exposure of CYP2C9 substrate Details Glipizide Chlorothiazide Diuril An increased risk of hyperglycemia and an increased insulin requirement Details Glipizide Chlorthalidone Hemiclor An increased risk of hyperglycemia and an increased insulin requirement Details Glipizide Ciprofloxacin Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Glipizide Dabrafenib Tafinlar Reduced sensitive CYP2C9 substrate exposure Details Glipizide Deutivacaftor Increased CYP2C9 substrate exposure Details Glipizide Doxifluridine Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Glipizide Dulaglutide Trulicity Increased risk of hypoglycemia Details Glipizide Enoxacin Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Glipizide Fluconazole Diflucan Increased glipiZIDE exposure and an increased risk of hypoglycemia Details Glipizide Furosemide Disal An increased risk of hyperglycemia and an increased insulin requirement Details Glipizide Gatifloxacin Zymaxid Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Glipizide Grepafloxacin Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Glipizide Hydrochlorothiazide Inzirqo An increased risk of hyperglycemia and an increased insulin requirement Details Glipizide Hydroflumethiazide An increased risk of hyperglycemia and an increased insulin requirement Details Glipizide Hydroxychloroquine Plaquenil Enhanced hypoglycemic effect of antidiabetics and an increased risk of hypoglycemia Details Glipizide Indapamide An increased risk of hyperglycemia and an increased insulin requirement Details Glipizide Insulin Afrezza An increased risk of hypoglycemia Details Glipizide Insulin Aspart, Recombinant Fiasp An increased risk of hypoglycemia Details Glipizide Insulin Bovine An increased risk of hypoglycemia Details

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