Gliquidone and Dulaglutide Injection: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Dulaglutide Injection
Gliquidone
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased risk of hypoglycemia
Interaction Deep Dive
Concomitant use of dulaglutide and a sulfonylurea may result in hypoglycemia. In clinical trials, hypoglycemia was reported in approximately 40% of patients with dulaglutide and sulfonylureas. Consider reducing the dosage of sulfonylureas when initiating dulaglutide to reduce risk1.
Why it happens (mechanism)
Additive hypoglycemia
Literature reports
1 report — tap to read
a) When dulaglutide was coadministered with a sulfonylurea during clinical trials, symptomatic hypoglycemia was reported in 39% (0.75 mg) and 40% (1.5 mg) of patients and severe hypoglycemia was reported in 0% (0.75 mg) and 0.7% (1.5 mg) of patients 1.
Common questions
Can I take Gliquidone and Dulaglutide Injection together?
Increased risk of hypoglycemia Always confirm with your pharmacist or prescriber before making any change.
How serious is the Gliquidone and Dulaglutide Injection interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "established". Well documented — supported by controlled studies or strong clinical data.
Questions for your pharmacist
- Does my dose of Gliquidone or Dulaglutide Injection need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: TRULICITY(TM) subcutaneous injection, dulaglutide subcutaneous injection. Eli Lilly and Company (per manufacturer), Indianapolis, IN, 2014. DailyMed
Keep reading about Dulaglutide Injection
Keep reading about Gliquidone
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