Gliquidone and Lixisenatide Injection: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Lixisenatide Injection
Gliquidone
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased risk of hypoglycemia
Interaction Deep Dive
Concomitant use of lixisenatide and a sulfonylurea may increase the risk of hypoglycemia. In patients who received a sulfonylurea with or without metformin, symptomatic hypoglycemia occurred in 14.5% of patients receiving concomitant lixisenatide compared with 10.6% of patients receiving placebo. Consider reducing the dose of the sulfonylurea if it is coadministered with lixisenatide1.
Why it happens (mechanism)
Additive anti-hyperglycemic effects
Literature reports
1 report — tap to read
a) In a clinical trial when both treatment groups received a sulfonylurea with or without metformin, symptomatic hypoglycemia was reported in 14.5% of patients receiving concomitant lixisenatide (n=656) compared with 10.6% of patients receiving placebo (n=377) 1.
Common questions
Can I take Gliquidone and Lixisenatide Injection together?
Increased risk of hypoglycemia Always confirm with your pharmacist or prescriber before making any change.
How serious is the Gliquidone and Lixisenatide Injection interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Gliquidone or Lixisenatide Injection need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: ADLYXIN(TM) subcutaneous injection, lixisenatide subcutaneous injection. sanofi-aventis US LLC (per manufacturer), Bridgewater, NJ, 2016. DailyMed
Keep reading about Lixisenatide Injection
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