Glucagon Injection and Paltusotine: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Glucagon Injection
Paltusotine
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
An increased risk of hypoglycemia or hyperglycemia or diabetes mellitus
Interaction Deep Dive
Concomitant use of paltusotine with glucagon may alter the balance between glucagon, which may result in hypoglycemia, hyperglycemia, or diabetes mellitus. Hyperglycemia was reported in participants treated with paltusotine in clinical trials. Monitor blood glucose levels when paltusotine treatment is initiated or when the dose is altered. Adjust antidiabetic treatment accordingly1.
Why it happens (mechanism)
Altered balance between the counter-regulatory hormones
Common questions
Can I take Glucagon Injection and Paltusotine together?
An increased risk of hypoglycemia or hyperglycemia or diabetes mellitus Always confirm with your pharmacist or prescriber before making any change.
How serious is the Glucagon Injection and Paltusotine interaction?
It is rated moderate. Can be significant — usually manageable with monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Glucagon Injection or Paltusotine need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there anything you'd monitor while I'm on both?
References (1)
- Product Information: PALSONIFY™ oral tablets, paltusotine oral tablets. Crinetics Pharmaceuticals, Inc (per FDA), San Diego, CA, 2025. DailyMed
Keep reading about Glucagon Injection
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