Paltusotine

33 interactions 3 explained in plain English

Also sold as: Palsonify

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Omeprazole Nafcillin Injection Esomeprazole Dexamethasone Injection Dexamethasone Ophthalmic Dexlansoprazole

12 Major 21 Moderate

All (33) Major (12) Moderate (21)

Major

Paltusotine Omeprazole Gastrobim Explained Reduced paltusotine exposure and reduced efficacy of paltusotine Details Paltusotine Cyclosporine Injection Atopica Reduced cycloSPORINE exposure Details Paltusotine Cyclosporine Ophthalmic Cequa Reduced cycloSPORINE exposure Details Paltusotine Dexamethasone Injection Decadron Reduced paltusotine exposure and reduced efficacy of paltusotine Details Paltusotine Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Reduced paltusotine exposure and reduced efficacy of paltusotine Details Paltusotine Dexlansoprazole Dexilant Reduced paltusotine exposure and reduced efficacy of paltusotine Details Paltusotine Encorafenib Braftovi Reduced paltusotine exposure and reduced efficacy of paltusotine Details Paltusotine Esomeprazole Nexium Reduced paltusotine exposure and reduced efficacy of paltusotine Details Paltusotine Esomeprazole Injection Nexium Reduced paltusotine exposure and reduced efficacy of paltusotine Details Paltusotine Lansoprazole Prevacid Reduced paltusotine exposure and reduced efficacy of paltusotine Details Paltusotine Mitapivat Aqvesme Reduced paltusotine exposure and reduced efficacy of paltusotine Details Paltusotine Nafcillin Injection Unipen® Injection Reduced paltusotine exposure and reduced efficacy of paltusotine Details

Moderate

Paltusotine Amitriptyline Elavil Explained An increased risk of PR interval prolongation Details Paltusotine Atenolol Tenormin Explained An increased risk of PR interval prolongation Details Paltusotine Acebutolol Sectral® An increased risk of PR interval prolongation Details Paltusotine Betaxolol Betoptic S An increased risk of PR interval prolongation Details Paltusotine Betaxolol Ophthalmic Betoptic® An increased risk of PR interval prolongation Details Paltusotine Bisoprolol Zebeta® An increased risk of PR interval prolongation Details Paltusotine Dolasetron Anzemet An increased risk of PR interval prolongation Details Paltusotine Dolasetron Injection Anzemet An increased risk of PR interval prolongation Details Paltusotine Esmolol Brevibloc An increased risk of PR interval prolongation Details Paltusotine Glucagon Injection Baqsimi An increased risk of hypoglycemia or hyperglycemia or diabetes mellitus Details Paltusotine Glucagon Injection / Solution Baqsimi An increased risk of hypoglycemia or hyperglycemia or diabetes mellitus Details Paltusotine Glucagon Nasal Powder Baqsimi An increased risk of hypoglycemia or hyperglycemia or diabetes mellitus Details Paltusotine Insulin Degludec (Rdna Origin) Injection Ryzodeg® (as a combination product containing Insulin Degludec and Insulin Aspart) An increased risk of hypoglycemia or hyperglycemia or diabetes mellitus Details Paltusotine Insulin Detemir (Rdna Origin) Injection Levemir An increased risk of hypoglycemia or hyperglycemia or diabetes mellitus Details Paltusotine Insulin Glulisine (Rdna Origin) Injection Apidra An increased risk of hypoglycemia or hyperglycemia or diabetes mellitus Details Paltusotine Labetalol Normodyne® An increased risk of PR interval prolongation Details Paltusotine Lacosamide Injection Motpoly An increased risk of PR interval prolongation Details Paltusotine Levobunolol Ophthalmic AKBeta® An increased risk of PR interval prolongation Details Paltusotine Nadolol Corgard An increased risk of PR interval prolongation Details Paltusotine Nebivolol Bystolic An increased risk of PR interval prolongation Details Paltusotine Penbutolol Levatol® An increased risk of PR interval prolongation Details

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