Glucarpidase

Name: Glucarpidase Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

3 interactions 9 cited references

Also sold as: Voraxaze Voraxaze®

About Glucarpidase

Glucarpidase is used to prevent harmful effects of methotrexate (Rheumatrex, Trexall) in patients with kidney disease who are receiving methotrexate to treat certain types of cancer. Glucarpidase is in a class of medications called enzymes. It works by helping to break down and remove methotrexate from the body. Read the full Glucarpidase drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Leucovorin Leucovorin Injection

2 Major 1 Moderate

All (3) Major (2) Moderate (1)

Major

Glucarpidase Leucovorin Vykoura Reduced leucovorin exposure and reduced efficacy of leucovorin Details Glucarpidase Leucovorin Injection Vykoura Reduced leucovorin exposure and reduced efficacy of leucovorin Details

Moderate

Glucarpidase Levoleucovorin Reduced levoleucovorin plasma concentrations Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.