Grepafloxacin

21 interactions 2 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Amitriptyline Acarbose Miglitol Nateglinide Dapagliflozin Dulaglutide Injection
1 Contraindicated 19 Major 1 Moderate
All (21) Contraindicated (1) Major (19) Moderate (1)

Contraindicated

Grepafloxacin Amitriptyline Elavil Explained An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details

Major

Grepafloxacin Acarbose Prandase® Explained Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Grepafloxacin Alogliptin Nesina Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Grepafloxacin Canagliflozin Invokana Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Grepafloxacin Dapagliflozin Farxiga Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Grepafloxacin Dulaglutide Injection Trulicity Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Grepafloxacin Empagliflozin Glyxambi® (as a combination product containing Empagliflozin and Linagliptin) Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Grepafloxacin Ertugliflozin Steglatro Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Grepafloxacin Exenatide Injection Bydureon Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Grepafloxacin Glimepiride Amaryl Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Grepafloxacin Glipizide Glucotrol Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Grepafloxacin Insulin Degludec (Rdna Origin) Injection Ryzodeg® (as a combination product containing Insulin Degludec and Insulin Aspart) Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Grepafloxacin Insulin Detemir (Rdna Origin) Injection Levemir Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Grepafloxacin Insulin Glulisine (Rdna Origin) Injection Apidra Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Grepafloxacin Linagliptin Tradjenta Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Grepafloxacin Liraglutide Injection Saxenda Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Grepafloxacin Lixisenatide Injection Adlyxin® Changes in blood glucose with an increased risk of hypoglycemia or hyperglycemia and delayed therapeutic effect of antibiotic Details Grepafloxacin Metformin Fortamet® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Grepafloxacin Miglitol Glyset® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Grepafloxacin Nateglinide Starlix® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details

Moderate

Grepafloxacin Didanosine Videx® Decreased grepafloxacin effectiveness Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.