Guanabenz

Name: Guanabenz Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

3 interactions 187 cited references

Also sold as: Wytensin®

About Guanabenz

Guanabenz is used to treat high blood pressure. It is in a class of medications called centrally acting alpha2A-adrenergic receptor agonists. Guanabenz works by decreasing your heart rate and relaxing the blood vessels so that blood can flow more easily through the body. High blood pressure is a common condition and wh… Read the full Guanabenz drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Iobenguane I 131

1 Major 2 Moderate

All (3) Major (1) Moderate (2)

Major

Guanabenz Iobenguane I 131 Azedra Inaccurate dosimetry calculations or reduced efficacy Details

Moderate

Guanabenz Ma Huang Increased blood pressure Details Guanabenz Yohimbine Reduced guanabenz effectiveness Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.