Guanethidine

Name: Guanethidine Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

5 interactions 1 explained in plain English

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Linezolid Injection

1 Contraindicated 4 Moderate

All (5) Contraindicated (1) Moderate (4)

Contraindicated

Guanethidine Linezolid Injection Zyvox Reduced antihypertensive response to guanethidine and an increased risk of hypertensive crisis Details

Moderate

Guanethidine Amitriptyline Elavil Explained Decreased antihypertensive effectiveness Details Guanethidine Diethylpropion Tenuate Decreased guanethidine effectiveness Details Guanethidine Glimepiride Amaryl Increased blood glucose lowering effect and risk of hypoglycemia Details Guanethidine Nateglinide Starlix® Increased risk of hypoglycemia Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.