Hydrochlorothiazide

89 interactions 5 explained in plain English
Also sold as: Inzirqo
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Dofetilide Mefenamic Acid Fenoprofen Nateglinide Glipizide Meloxicam
1 Contraindicated 55 Major 33 Moderate
All (89) Contraindicated (1) Major (55) Moderate (33)

Major

Hydrochlorothiazide Linagliptin Tradjenta An increased risk of hyperglycemia and an increased insulin requirement Details Hydrochlorothiazide Liraglutide Injection Saxenda An increased risk of hyperglycemia and an increased insulin requirement Details Hydrochlorothiazide Lithium Carbonate Lithobid Lithium toxicity Details Hydrochlorothiazide Lixisenatide Injection Adlyxin® An increased risk of hyperglycemia and an increased insulin requirement Details Hydrochlorothiazide Meclofenamate Meclodium® Reduced diuretic effectiveness and possible nephrotoxicity Details Hydrochlorothiazide Mefenamic Acid Ponstel® Reduced diuretic effectiveness and possible nephrotoxicity Details Hydrochlorothiazide Meloxicam Alloxate Reduced diuretic effectiveness and possible nephrotoxicity Details Hydrochlorothiazide Meloxicam Injection Alloxate Reduced diuretic effectiveness and possible nephrotoxicity Details Hydrochlorothiazide Methotrexate Jylamvo Increased methotrexate exposure and enhanced myelosuppression Details Hydrochlorothiazide Methotrexate Injection Abitrexate® Increased methotrexate exposure and enhanced myelosuppression Details Hydrochlorothiazide Miglitol Glyset® An increased risk of hyperglycemia and an increased insulin requirement Details Hydrochlorothiazide Morphine Injection Astramorph® PF Reduced efficacy of diuretics Details Hydrochlorothiazide Nabumetone Relafen Reduced diuretic effectiveness and possible nephrotoxicity Details Hydrochlorothiazide Naproxen Aleve Reduced diuretic effectiveness and possible nephrotoxicity Details Hydrochlorothiazide Nateglinide Starlix® An increased risk of hyperglycemia and an increased insulin requirement Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.