Hydroflumethiazide
66 interactions 5 explained in plain English
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Mefenamic Acid
Fenoprofen
Nateglinide
Hydromorphone Injection
Glipizide
Meloxicam
Major
Hydroflumethiazide Acetaminophen And Codeine Capital® & Codeine Explained Reduced diuretic efficacy Details Hydroflumethiazide Albuterol Oral Inhalation Accuneb® Explained An increased risk of ECG changes or hypokalemia Details Hydroflumethiazide Buprenorphine Belbuca Explained Reduced efficacy of diuretics Details Hydroflumethiazide Acarbose Prandase® Explained An increased risk of hyperglycemia and an increased insulin requirement Details Hydroflumethiazide Arsenic Trioxide Trisenox Increased risk of QT-interval prolongation and torsade de pointes Details Hydroflumethiazide Arsenic Trioxide Injection Trisenox Increased risk of QT-interval prolongation and torsade de pointes Details Hydroflumethiazide Aspirin Acuprin® Reduced diuretic effectiveness and possible nephrotoxicity Details Hydroflumethiazide Aspirin Rectal Aspirin Reduced diuretic effectiveness and possible nephrotoxicity Details Hydroflumethiazide Alogliptin Nesina An increased risk of hyperglycemia and an increased insulin requirement Details Hydroflumethiazide Bromfenac Ophthalmic Bromday® Reduced diuretic effectiveness and possible nephrotoxicity Details Hydroflumethiazide Canagliflozin Invokana An increased risk of hyperglycemia and an increased insulin requirement Details Hydroflumethiazide Cefepime Injection Maxipime® An increased risk of nephrotoxicity Details Hydroflumethiazide Dapagliflozin Farxiga An increased risk of hyperglycemia and an increased insulin requirement Details Hydroflumethiazide Diclofenac Ophthalmic Voltaren® Eye Drops Reduced diuretic effectiveness and possible nephrotoxicity Details Hydroflumethiazide Diclofenac Topical (Actinic Keratosis) Pennsaid Reduced diuretic effectiveness and possible nephrotoxicity Details Hydroflumethiazide Diclofenac Topical (Arthritis Pain) Pennsaid® Reduced diuretic effectiveness and possible nephrotoxicity Details Hydroflumethiazide Diclofenac Transdermal Patch Flector Reduced diuretic effectiveness and possible nephrotoxicity Details Hydroflumethiazide Digoxin Cardoxin® Increased risk of digitalis toxicity (nausea, vomiting, arrhythmias) Details Hydroflumethiazide Dulaglutide Injection Trulicity An increased risk of hyperglycemia and an increased insulin requirement Details Hydroflumethiazide Empagliflozin Glyxambi® (as a combination product containing Empagliflozin and Linagliptin) An increased risk of hyperglycemia and an increased insulin requirement Details Hydroflumethiazide Etodolac Lodine Reduced diuretic effectiveness and possible nephrotoxicity Details Hydroflumethiazide Exenatide Injection Bydureon An increased risk of hyperglycemia and an increased insulin requirement Details Hydroflumethiazide Fenoprofen Fenopron Reduced diuretic effectiveness and possible nephrotoxicity Details Hydroflumethiazide Fentanyl Transdermal Patch Duragesic® Reduced diuretic efficacy Details Hydroflumethiazide Flecainide Tambocor® Increased risk of electrolyte imbalance and subsequent cardiotoxicity Details Hydroflumethiazide Flurbiprofen Ansaid Reduced diuretic effectiveness and possible nephrotoxicity Details Hydroflumethiazide Flurbiprofen Ophthalmic Ocufen Reduced diuretic effectiveness and possible nephrotoxicity Details Hydroflumethiazide Glimepiride Amaryl An increased risk of hyperglycemia and an increased insulin requirement Details Hydroflumethiazide Glipizide Glucotrol An increased risk of hyperglycemia and an increased insulin requirement Details Hydroflumethiazide Hydromorphone Injection Dilaudid Reduced efficacy of diuretics Details Hydroflumethiazide Hydromorphone Rectal available generically Reduced efficacy of diuretics Details Hydroflumethiazide Ibuprofen Addaprin Reduced diuretic effectiveness and possible nephrotoxicity Details Hydroflumethiazide Insulin Degludec (Rdna Origin) Injection Ryzodeg® (as a combination product containing Insulin Degludec and Insulin Aspart) An increased risk of hyperglycemia and an increased insulin requirement Details Hydroflumethiazide Insulin Detemir (Rdna Origin) Injection Levemir An increased risk of hyperglycemia and an increased insulin requirement Details Hydroflumethiazide Insulin Glulisine (Rdna Origin) Injection Apidra An increased risk of hyperglycemia and an increased insulin requirement Details Hydroflumethiazide Ketoprofen Actron® Reduced diuretic effectiveness and possible nephrotoxicity Details Hydroflumethiazide Ketorolac Acular Reduced diuretic effectiveness and possible nephrotoxicity Details Hydroflumethiazide Ketorolac Injection Acular Reduced diuretic effectiveness and possible nephrotoxicity Details Hydroflumethiazide Ketorolac Nasal Spray Sprix Reduced diuretic effectiveness and possible nephrotoxicity Details Hydroflumethiazide Ketorolac Ophthalmic Acular Reduced diuretic effectiveness and possible nephrotoxicity DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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