Hydroflumethiazide

66 interactions 5 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Mefenamic Acid Fenoprofen Nateglinide Hydromorphone Injection Glipizide Meloxicam
53 Major 13 Moderate
All (66) Major (53) Moderate (13)

Major

Hydroflumethiazide Linagliptin Tradjenta An increased risk of hyperglycemia and an increased insulin requirement Details Hydroflumethiazide Liraglutide Injection Saxenda An increased risk of hyperglycemia and an increased insulin requirement Details Hydroflumethiazide Lithium Carbonate Lithobid Lithium toxicity Details Hydroflumethiazide Lixisenatide Injection Adlyxin® An increased risk of hyperglycemia and an increased insulin requirement Details Hydroflumethiazide Meclofenamate Meclodium® Reduced diuretic effectiveness and possible nephrotoxicity Details Hydroflumethiazide Mefenamic Acid Ponstel® Reduced diuretic effectiveness and possible nephrotoxicity Details Hydroflumethiazide Meloxicam Alloxate Reduced diuretic effectiveness and possible nephrotoxicity Details Hydroflumethiazide Meloxicam Injection Alloxate Reduced diuretic effectiveness and possible nephrotoxicity Details Hydroflumethiazide Miglitol Glyset® An increased risk of hyperglycemia and an increased insulin requirement Details Hydroflumethiazide Morphine Injection Astramorph® PF Reduced efficacy of diuretics Details Hydroflumethiazide Nabumetone Relafen Reduced diuretic effectiveness and possible nephrotoxicity Details Hydroflumethiazide Naproxen Aleve Reduced diuretic effectiveness and possible nephrotoxicity Details Hydroflumethiazide Nateglinide Starlix® An increased risk of hyperglycemia and an increased insulin requirement Details

Moderate

Hydroflumethiazide Lisinopril Prinivil Explained Reduction of blood pressure Details Hydroflumethiazide Asenapine Transdermal Patch Secuado An increased risk of hypotension Details Hydroflumethiazide Benazepril Lotensin Reduction of blood pressure Details Hydroflumethiazide Captopril Capoten® Reduction of blood pressure Details Hydroflumethiazide Cyclophosphamide Cytoxan® Increased risk of myelosuppression Details Hydroflumethiazide Cyclophosphamide Injection Cytoxan® Injection Increased risk of myelosuppression Details Hydroflumethiazide Desmopressin Nasal Concentraid® Increased risk of water intoxication with hyponatremia Details Hydroflumethiazide Dofetilide Tikosyn An increased risk of hypokalemia or hypomagnesemia and an increased risk of torsade de pointes Details Hydroflumethiazide Enalapril Epaned Reduction of blood pressure Details Hydroflumethiazide Fosinopril Monopril® Reduction of blood pressure Details Hydroflumethiazide Metformin Fortamet® An increased risk of hyperglycemia and potential loss of glycemic control Details Hydroflumethiazide Moexipril Univasc® Reduction of blood pressure Details Hydroflumethiazide Perindopril Aceon Reduction of blood pressure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.