Drug Interaction Report

Miglitol and Hydroflumethiazide: Interaction Details

A pharmacist-reviewed analysis of the Miglitol and Hydroflumethiazide interaction: the documented clinical effects, severity rating, onset, mechanism, and management considerations, with cited references throughout.

AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature

Hydroflumethiazide

No brand names on record
+

Miglitol

Glyset®
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
Updated Aug 8, 2026
Editorial policy · Data sources
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Interaction severity
Major
Potentially serious — often needs a change or close monitoring.
How we grade severity & evidence

Severity levels

  • Contraindicated: These should generally not be used together.
  • Major: Potentially serious — often needs a change or close monitoring.
  • Moderate: Can be significant — usually manageable with monitoring.
  • Minor: Usually limited clinical impact.

Evidence grades

  • Established: Well documented — supported by controlled studies or strong clinical data.
  • Probable: Good supporting evidence, though not definitively proven.
  • Suspected: Some evidence suggests this interaction, but it is not well established.
  • Possible: Limited or conflicting evidence; the interaction may occur.
  • Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.

Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.

Of 107 documented Miglitol interactions, 57 are rated major — including this one.
Worried about symptoms right now? Contact your pharmacist or prescriber, or call Poison Control at 1-800-222-1222 (US). Call 911 for an emergency.
Onset
unspecified
Evidence
theoretical
Severity
Major

What happens

An increased risk of hyperglycemia and an increased insulin requirement

Interaction Deep Dive

Certain diuretic agents may alter glucose tolerance or blood glucose levels, possibly predisposing the patient to hyperglycemia or loss of glycemic control. Insulin requirements may be increased123, decreased, or unchanged 4. If concomitant use of a certain diuretic and an antidiabetic agent is required, monitor glucose levels more frequently, including upon withdrawal of the diuretic 56. Dose adjustment of oral antidiabetic agents or insulin may be required 78.

Why it happens (mechanism)

Altered glucose metabolism

Common questions

Can I take Miglitol and Hydroflumethiazide together?

An increased risk of hyperglycemia and an increased insulin requirement Always confirm with your pharmacist or prescriber before making any change.

How serious is the Miglitol and Hydroflumethiazide interaction?

It is rated major. Potentially serious — often needs a change or close monitoring.

How quickly could this interaction happen?

The documented onset is "unspecified". The timing of this interaction is not well characterized.

How strong is the evidence for this interaction?

The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.

Questions for your pharmacist

  • Does my dose of Miglitol or Hydroflumethiazide need adjusting while I take them together?
  • What symptoms should prompt me to call you or my prescriber right away?
  • Does the timing of my doses matter for this combination?
  • Is there a safer alternative to one of these medications for me?

References (8)

  1. Product Information: TOUJEO(R) subcutaneous injection, insulin glargine subcutaneous injection. sanofi-aventis (per manufacturer), Bridgewater, NJ, 2015. DailyMed
  2. Product Information: Tresiba subcutaneous injection solution, insulin degludec subcutaneous injection solution. Novo Nordisk A/S (per EMA), Bagsvaerd, Denmark, 2013. DailyMed
  3. Product Information: SEMGLEE(R) subcutaneous injection, insulin glargine-yfgn subcutaneous injection. Mylan Pharmaceuticals Inc (per FDA), Morgantown, WV, 2023. DailyMed
  4. Product Information: chlorthalidone oral tablets, chlorthalidone oral tablets. Pliva,Inc, East Hanover, NJ, 2004. DailyMed
  5. Product Information: XIGDUO(TM) XR oral extended release tablets, dapagliflozin metformin HCl oral extended release tablets. AstraZeneca Pharmaceuticals LP (per manufacturer), Wilmington, DE, 2014. DailyMed
  6. Product Information: GLUMETZA(R) oral extended-release tablets, metformin HCl oral extended-release tablets. Santarus, Inc. (per Manufacturer), San Diego, CA, 2013. DailyMed
  7. Product Information: ACCURETIC(TM) oral tablets, quinapril HCl hydrochlorothiazide oral tablets. Parke-Davis (per FDA), New York, NY, 2015.
  8. Product Information: DYRENIUM(R) oral capsules, triamterene oral capsules. Wellspring Pharmaceutical Corporation, Ontario, Canada, 2005. DailyMed
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Hydroflumethiazide

Keep reading about Hydroflumethiazide

All Hydroflumethiazide interactions (66)
Also serious with: Glipizide Mefenamic Acid Fenoprofen Hydromorphone Injection
Miglitol

Keep reading about Miglitol

All Miglitol interactions (107) Miglitol drug information
Also serious with: Hydrochlorothiazide Indapamide Grepafloxacin Ofloxacin Otic
Beyond drug–drug

These medications also interact with supplements

Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:

Hydroflumethiazide + Activated Charcoal American Hellebore American Mistletoe Asarabacca Dolomite Lithium Oleander Siberian Cocklebur + 219 more
Miglitol + Activated Charcoal Siberian Cocklebur Acai African Wild Potato Agaricus Mushroom Agmatine Agrimony Alfalfa + 248 more

major · moderate · minor — check everything you take with our drug–supplement interaction checker.

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This information is for education, not a substitute for professional medical advice. Do not start, stop, or change any medication without talking to your pharmacist or prescriber.