Hydroxychloroquine

631 interactions 1 explained in plain English 236 cited references

Also sold as: Plaquenil Plaquenil® Sovuna

About Hydroxychloroquine

Hydroxychloroquine is an antimalarial and antirheumatic drug used to prevent and treat malaria, lupus, and rheumatoid arthritis. Read the full Hydroxychloroquine drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Bepridil Ziprasidone Mesoridazine Levoketoconazole Cisapride Aurothioglucose

13 Contraindicated 616 Major 2 Moderate

All (631) Contraindicated (13) Major (616) Moderate (2)

Major

Hydroxychloroquine Mepenzolate An increased risk of seizures Details Hydroxychloroquine Meperidine Demerol An increased risk of seizures Details Hydroxychloroquine Mercaptopurine Purinethol® An increased risk of hepatotoxicity Details Hydroxychloroquine Mestranol An increased risk of seizures Details Hydroxychloroquine Metformin Fortamet® Enhanced hypoglycemic effect of antidiabetics and an increased risk of hypoglycemia Details Hydroxychloroquine Methadone Diskets Increased risk of QT interval prolongation Details Hydroxychloroquine Methantheline An increased risk of seizures Details Hydroxychloroquine Methdilazine An increased risk of seizures Details Hydroxychloroquine Methicillin An increased risk of seizures Details Hydroxychloroquine Methixene An increased risk of seizures Details Hydroxychloroquine Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Hydroxychloroquine Methotrimeprazine An increased risk of seizures and an increased risk of QT interval prolongation Details Hydroxychloroquine Methsuximide Celontin Impaired antiepileptic activity Details Hydroxychloroquine Methylphenidate Adhansia XR® An increased risk of seizures Details Hydroxychloroquine Metopimazine An increased risk of seizures Details Hydroxychloroquine Metronidazole Flagyl An increased risk of seizures and an increased risk of QT interval prolongation Details Hydroxychloroquine Mezlocillin An increased risk of seizures Details Hydroxychloroquine Midazolam Impaired antiepileptic activity Details Hydroxychloroquine Midazolam Hydrochloride Impaired antiepileptic activity Details Hydroxychloroquine Mifepristone Korlym Increased risk of QT interval prolongation Details Hydroxychloroquine Miglitol Glyset® Enhanced hypoglycemic effect of antidiabetics and an increased risk of hypoglycemia Details Hydroxychloroquine Milnacipran Savella An increased risk of seizures Details Hydroxychloroquine Milsaperidone An increased risk of QT interval prolongation Details Hydroxychloroquine Mirtazapine Mirataz Increased risk of QT interval prolongation and torsades de pointes and an increased risk of seizures Details Hydroxychloroquine Mizolastine An increased risk of seizures and an increased risk of QT interval prolongation Details Hydroxychloroquine Mobocertinib Exkivity An increased risk of QT interval prolongation Details Hydroxychloroquine Moricizine Increased risk of QT interval prolongation Details Hydroxychloroquine Morphine An increased risk of seizures Details Hydroxychloroquine Moxifloxacin Avelox An increased risk of seizures and an increased risk of QT interval prolongation Details Hydroxychloroquine Nadifloxacin An increased risk of seizures Details Hydroxychloroquine Nafarelin Increased risk of QT interval prolongation Details Hydroxychloroquine Nafcillin An increased risk of seizures Details Hydroxychloroquine Nalbuphine An increased risk of seizures Details Hydroxychloroquine Nalidixic Acid An increased risk of seizures Details Hydroxychloroquine Nateglinide Starlix® Enhanced hypoglycemic effect of antidiabetics and an increased risk of hypoglycemia Details Hydroxychloroquine Nefazodone An increased risk of seizures Details Hydroxychloroquine Nelfinavir Viracept Increased risk of QT interval prolongation Details Hydroxychloroquine Neostigmine An increased risk of seizures Details Hydroxychloroquine Niaprazine An increased risk of seizures Details Hydroxychloroquine Nilotinib Increased risk of QT interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.