Hydroxychloroquine

631 interactions 1 explained in plain English 236 cited references

Also sold as: Plaquenil Plaquenil® Sovuna

About Hydroxychloroquine

Hydroxychloroquine is an antimalarial and antirheumatic drug used to prevent and treat malaria, lupus, and rheumatoid arthritis. Read the full Hydroxychloroquine drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Bepridil Ziprasidone Mesoridazine Levoketoconazole Cisapride Aurothioglucose

13 Contraindicated 616 Major 2 Moderate

All (631) Contraindicated (13) Major (616) Moderate (2)

Major

Hydroxychloroquine Amitriptyline Elavil Increased risk of QT interval prolongation Details Hydroxychloroquine Sertraline An increased risk of seizures and an increased risk of QT interval prolongation Details Hydroxychloroquine Buprenorphine Belbuca An increased risk of seizures and an increased risk of QT interval prolongation Details Hydroxychloroquine Relugolix Orgovyx Increased risk of QT interval prolongation Details Hydroxychloroquine Trospium / Xanomeline Cobenfy Explained An increased risk of seizures Details Hydroxychloroquine Acarbose Prandase® Enhanced hypoglycemic effect of antidiabetics and an increased risk of hypoglycemia Details Hydroxychloroquine Acetazolamide Diamox® Sequels® Impaired antiepileptic activity Details Hydroxychloroquine Acyclovir Avaclyr An increased risk of seizures Details Hydroxychloroquine Acyclovir Injection Avaclyr An increased risk of seizures Details Hydroxychloroquine Acyclovir Ophthalmic Avaclyr An increased risk of seizures Details Hydroxychloroquine Acyclovir Topical Zovirax An increased risk of seizures Details Hydroxychloroquine Alcaftadine Ophthalmic Lastacaft An increased risk of seizures Details Hydroxychloroquine Amisulpride Injection Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Hydroxychloroquine Ampicillin Amcill® Reduced hydroxychloroquine bioavailability and an increased risk of seizures Details Hydroxychloroquine Ampicillin Injection Omnipen-N® Reduced hydroxychloroquine bioavailability and an increased risk of seizures Details Hydroxychloroquine Arsenic Trioxide Trisenox Increased risk of QT interval prolongation Details Hydroxychloroquine Aripiprazole Injection Abilify Increased risk of QT interval prolongation Details Hydroxychloroquine Arsenic Trioxide Injection Trisenox Increased risk of QT interval prolongation Details Hydroxychloroquine Asenapine Transdermal Patch Secuado Increased risk of QT interval prolongation Details Hydroxychloroquine Atovaquone Mepron An increased risk of seizures Details Hydroxychloroquine Azathioprine Azasan An increased risk of hepatotoxicity Details Hydroxychloroquine Azithromycin AzaSite Increased risk of QT interval prolongation Details Hydroxychloroquine Aztreonam Injection Azactam An increased risk of seizures Details Hydroxychloroquine Aclidinium Oral Inhalation Tudorza An increased risk of seizures Details Hydroxychloroquine Alfuzosin UroXatral Increased risk of QT interval prolongation Details Hydroxychloroquine Alogliptin Nesina Enhanced hypoglycemic effect of antidiabetics and an increased risk of hypoglycemia Details Hydroxychloroquine Amphotericin B Injection Abelcet An increased risk of seizures Details Hydroxychloroquine Anagrelide Agrylin Increased risk of QT interval prolongation Details Hydroxychloroquine Azelastine Nasal Spray Astelin® Nasal Spray An increased risk of seizures Details Hydroxychloroquine Azelastine Ophthalmic Optivar® An increased risk of seizures Details Hydroxychloroquine Atropine Ophthalmic Atropine Care 1% An increased risk of seizures Details Hydroxychloroquine Bedaquiline Sirturo Increased risk of QT interval prolongation Details Hydroxychloroquine Besifloxacin Ophthalmic Besivance An increased risk of seizures Details Hydroxychloroquine Bepotastine Ophthalmic Bepreve An increased risk of seizures Details Hydroxychloroquine Brivaracetam Briviact Impaired antiepileptic activity Details Hydroxychloroquine Brivaracetam Injection Briviact Impaired antiepileptic activity Details Hydroxychloroquine Busulfan Injection Busulfex An increased risk of seizures Details Hydroxychloroquine Butorphanol Injection Butorphic An increased risk of seizures Details Hydroxychloroquine Butorphanol Nasal Spray Stadol® NS An increased risk of seizures Details Hydroxychloroquine Canagliflozin Invokana Enhanced hypoglycemic effect of antidiabetics and an increased risk of hypoglycemia Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.