Cesium - Plaquenil (Hydroxychloroquine) Interaction

Interaction Details

Hydroxychloroquine is classified as belonging to the following category: Qt Interval-Prolonging Drugs

Theoretically, taking cesium concomitantly with other drugs that prolong the QT interval may increase the risk of ventricular arrhythmias and death.
Taking cesium can prolong the QT interval on electrocardiogram (ECG). In many cases, cesium-induced QT prolongation has led to serious adverse effects, including torsades de pointes, cardiac arrest, and death.

Interaction Rating

Likelihood of Occurrence

Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.

References

• Lyon AW, Mayhew WJ. Cesium toxicity: A case of self-treatment by alternate therapy gone awry. Ther Drug Monit 2003;25:114-6.
• Vyas H, Johnson K, Houlihan R, et al. Acquired long QT syndrome secondary to cesium chloride supplement. J Altern Complement Med 2006;12:1011-4.
• Pinter A, Dorian P, Newman D. Cesium-induced torsades de pointes. N Engl J Med 2002;346:383-4.
• O'Brien CE, Harik N, James LP, et al. Cesium-induced QT-interval prolongation in an adolescent. Pharmacotherapy 2008;28:1059-65.
• FDA alerts health care professionals of significant safety risks associated with cesium chloride. FDA: Human Drug Compounding. July 23,2018. Available at: https://www.fda.gov/drugs/human-drug-compounding/fda-alerts-health-care-professionals-significant-sa
• Public Health Alert Concerning Dietary Supplements Containing Cesium Salts. FDA Dietary Supplement Products & Ingredients. February 5, 2020. Available at: https://www.fda.gov/food/dietary-supplement-products-ingredients/public-health-alert-concerning-diet

Hydroxychloroquine Overview

• Hydroxychloroquine is used to prevent and treat acute attacks of malaria in adults and children weighing more than 31 kg (68 lbs). It is also used to treat discoid lupus erythematosus (DLE; a chronic inflammatory condition of the skin) or systemic lupus erythematosus (SLE or lupus; an autoimmune disease in which the immune system attacks healthy parts of the body such as joints, skin, blood vessels, and organs) and rheumatoid arthritis. Hydroxychloroquine is in a class of drugs called antimalarials and is also an antirheumatic drug. It works by killing the organisms that cause malaria. Hydroxychloroquine may work to treat rheumatoid arthritis and systemic lupus erythematosus by decreasing the activity of the immune system.

Cesium - More Interactions

Cesium interacts with 251 drugs

Interaction Rating Key

These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.