Hydroxychloroquine

631 interactions 1 explained in plain English 236 cited references

Also sold as: Plaquenil Plaquenil® Sovuna

About Hydroxychloroquine

Hydroxychloroquine is an antimalarial and antirheumatic drug used to prevent and treat malaria, lupus, and rheumatoid arthritis. Read the full Hydroxychloroquine drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Bepridil Ziprasidone Mesoridazine Levoketoconazole Cisapride Aurothioglucose

13 Contraindicated 616 Major 2 Moderate

All (631) Contraindicated (13) Major (616) Moderate (2)

Major

Hydroxychloroquine Quetiapine Seroquel An increased risk of seizures and an increased risk of QT interval prolongation Details Hydroxychloroquine Quinestrol An increased risk of seizures Details Hydroxychloroquine Quinidine Cardioquin® Increased risk of QT interval prolongation Details Hydroxychloroquine Quinine Increased risk of QT interval prolongation Details Hydroxychloroquine Quizartinib Vanflyta An increased risk of QT interval prolongation Details Hydroxychloroquine Ranolazine Aspruzyo Increased risk of QT interval prolongation Details Hydroxychloroquine Remdesivir Reduced antiviral activity of remdesivir Details Hydroxychloroquine Remifentanil An increased risk of seizures Details Hydroxychloroquine Repaglinide Prandin® Enhanced hypoglycemic effect of antidiabetics and an increased risk of hypoglycemia Details Hydroxychloroquine Revumenib Revuforj An increased risk of QT interval prolongation Details Hydroxychloroquine Ribociclib Kisqali An increased risk of QT interval prolongation Details Hydroxychloroquine Rifampin Rifadin Decreased efficacy of hydroxychloroquine Details Hydroxychloroquine Rilpivirine Edurant Increased risk of QT interval prolongation Details Hydroxychloroquine Risperidone Perseris Increased risk of QT interval prolongation Details Hydroxychloroquine Ritonavir Norvir Increased risk of QT interval prolongation Details Hydroxychloroquine Rivastigmine Exelon An increased risk of seizures Details Hydroxychloroquine Rosiglitazone Avandia® Enhanced hypoglycemic effect of antidiabetics and an increased risk of hypoglycemia Details Hydroxychloroquine Rufinamide Banzel Impaired antiepileptic activity Details Hydroxychloroquine Rufloxacin An increased risk of seizures Details Hydroxychloroquine Safinamide Xadago An increased risk of seizures Details Hydroxychloroquine Saxagliptin Onglyza Enhanced hypoglycemic effect of antidiabetics and an increased risk of hypoglycemia Details Hydroxychloroquine Scopolamine Pamine An increased risk of seizures Details Hydroxychloroquine Selpercatinib Retevmo Increased risk of QT interval prolongation Details Hydroxychloroquine Semaglutide Ozempic Enhanced hypoglycemic effect of antidiabetics and an increased risk of hypoglycemia Details Hydroxychloroquine Sertindole Increased risk of QT interval prolongation Details Hydroxychloroquine Sevoflurane Petrem An increased risk of seizures and an increased risk of QT interval prolongation Details Hydroxychloroquine Sibutramine An increased risk of seizures Details Hydroxychloroquine Siponimod Mayzent An increased risk of QT interval prolongation Details Hydroxychloroquine Sitagliptin Brynovin Enhanced hypoglycemic effect of antidiabetics and an increased risk of hypoglycemia Details Hydroxychloroquine Sodium Bicarbonate Alka-Seltzer® Heartburn Reduced hydroxychloroquine exposure Details Hydroxychloroquine Sodium Phosphate OsmoPrep Increased risk of QT interval prolongation Details Hydroxychloroquine Sodium Phosphate, Dibasic Increased risk of QT interval prolongation Details Hydroxychloroquine Sodium Phosphate, Monobasic Increased risk of QT interval prolongation Details Hydroxychloroquine Solifenacin Vesicare An increased risk of seizures and an increased risk of QT interval prolongation Details Hydroxychloroquine Sorafenib Nexavar Increased risk of QT interval prolongation Details Hydroxychloroquine Sotalol Betapace An increased risk of QT interval prolongation Details Hydroxychloroquine Stiripentol Diacomit Impaired antiepileptic activity Details Hydroxychloroquine Sufentanil Dsuvia An increased risk of seizures Details Hydroxychloroquine Sulbenicillin An increased risk of seizures Details Hydroxychloroquine Sulpiride An increased risk of QT interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.