Hydroxychloroquine

631 interactions 1 explained in plain English 236 cited references
Also sold as: Plaquenil Plaquenil® Sovuna
About Hydroxychloroquine

Hydroxychloroquine is an antimalarial and antirheumatic drug used to prevent and treat malaria, lupus, and rheumatoid arthritis. Read the full Hydroxychloroquine drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Bepridil Ziprasidone Mesoridazine Levoketoconazole Cisapride Aurothioglucose
13 Contraindicated 616 Major 2 Moderate
All (631) Contraindicated (13) Major (616) Moderate (2)

Major

Hydroxychloroquine Chlorambucil Leukeran An increased risk of seizures Details Hydroxychloroquine Chloroquine Aralen® An increased risk of seizures and an increased risk of QT interval prolongation Details Hydroxychloroquine Cyclopentolate Ophthalmic Akpentolate® An increased risk of seizures Details Hydroxychloroquine Cyclosporine Injection Atopica Increased cycloSPORINE exposure and an increased risk of seizures Details Hydroxychloroquine Cyclosporine Ophthalmic Cequa Increased cycloSPORINE exposure and an increased risk of seizures Details Hydroxychloroquine Dalfampridine Ampyra An increased risk of seizures Details Hydroxychloroquine Dapagliflozin Farxiga Enhanced hypoglycemic effect of antidiabetics and an increased risk of hypoglycemia Details Hydroxychloroquine Dasatinib Phyrago Increased risk of QT interval prolongation Details Hydroxychloroquine Degarelix Injection Firmagon Increased risk of QT interval prolongation Details Hydroxychloroquine Deutetrabenazine Austedo An increased risk of QT interval prolongation Details Hydroxychloroquine Diazepam Nasal Spray Valtoco Impaired antiepileptic activity Details Hydroxychloroquine Diazepam Rectal Diastat Impaired antiepileptic activity Details Hydroxychloroquine Digoxin Cardoxin® Increased digoxin exposure Details Hydroxychloroquine Diphenhydramine Injection Banophen An increased risk of seizures Details Hydroxychloroquine Diphenhydramine Topical Afterbite with Antihistamine An increased risk of seizures Details Hydroxychloroquine Disopyramide Norpace Increased risk of QT interval prolongation Details Hydroxychloroquine Dofetilide Tikosyn Increased risk of QT interval prolongation Details Hydroxychloroquine Dolasetron Anzemet Increased risk of QT interval prolongation Details Hydroxychloroquine Dolasetron Injection Anzemet Increased risk of QT interval prolongation Details Hydroxychloroquine Dulaglutide Injection Trulicity Enhanced hypoglycemic effect of antidiabetics and an increased risk of hypoglycemia Details Hydroxychloroquine Empagliflozin Glyxambi® (as a combination product containing Empagliflozin and Linagliptin) Enhanced hypoglycemic effect of antidiabetics and an increased risk of hypoglycemia Details Hydroxychloroquine Encorafenib Braftovi Increased risk of QT interval prolongation Details Hydroxychloroquine Entrectinib Rozlytrek An increased risk of QT interval prolongation Details Hydroxychloroquine Epinastine Ophthalmic Elestat® An increased risk of seizures Details Hydroxychloroquine Eribulin Injection Halaven Increased risk of QT interval prolongation Details Hydroxychloroquine Ertugliflozin Steglatro Enhanced hypoglycemic effect of antidiabetics and an increased risk of hypoglycemia Details Hydroxychloroquine Estradiol Delestrogen An increased risk of seizures Details Hydroxychloroquine Estradiol Topical Divigel An increased risk of seizures Details Hydroxychloroquine Estradiol Transdermal Patch Alora® An increased risk of seizures Details Hydroxychloroquine Estramustine Emcyt An increased risk of seizures Details Hydroxychloroquine Ethosuximide Zarontin Impaired antiepileptic activity Details Hydroxychloroquine Etomidate An increased risk of seizures Details Hydroxychloroquine Exenatide Injection Bydureon Enhanced hypoglycemic effect of antidiabetics and an increased risk of hypoglycemia Details Hydroxychloroquine Famotidine Calmicid Increased risk of QT interval prolongation Details Hydroxychloroquine Famotidine Injection Calmicid Increased risk of QT interval prolongation Details Hydroxychloroquine Felbamate Felbatol Impaired antiepileptic activity and an increased risk of QT interval prolongation Details Hydroxychloroquine Fentanyl Transdermal Patch Duragesic® An increased risk of seizures Details Hydroxychloroquine Flecainide Tambocor® Increased risk of QT interval prolongation Details Hydroxychloroquine Foscarnet Injection Foscavir An increased risk of seizures and an increased risk of QT interval prolongation Details Hydroxychloroquine Fostemsavir Rukobia Increased risk of torsade de pointes Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.