Hydroxychloroquine

631 interactions 1 explained in plain English 236 cited references

Also sold as: Plaquenil Plaquenil® Sovuna

About Hydroxychloroquine

Hydroxychloroquine is an antimalarial and antirheumatic drug used to prevent and treat malaria, lupus, and rheumatoid arthritis. Read the full Hydroxychloroquine drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Bepridil Ziprasidone Mesoridazine Levoketoconazole Cisapride Aurothioglucose

13 Contraindicated 616 Major 2 Moderate

All (631) Contraindicated (13) Major (616) Moderate (2)

Major

Hydroxychloroquine Galantamine Razadyne An increased risk of seizures and an increased risk of QT interval prolongation Details Hydroxychloroquine Ganciclovir Cytovene® Oral An increased risk of seizures Details Hydroxychloroquine Ganciclovir Injection Cytovene® I.V.® An increased risk of seizures Details Hydroxychloroquine Ganciclovir Ophthalmic Zirgan An increased risk of seizures Details Hydroxychloroquine Gatifloxacin Ophthalmic Zymar® An increased risk of seizures and an increased risk of QT interval prolongation Details Hydroxychloroquine Gemifloxacin Factive Increased risk of QT interval prolongation Details Hydroxychloroquine Glasdegib Daurismo Increased risk of QT interval prolongation Details Hydroxychloroquine Glimepiride Amaryl Enhanced hypoglycemic effect of antidiabetics and an increased risk of hypoglycemia Details Hydroxychloroquine Glipizide Glucotrol Enhanced hypoglycemic effect of antidiabetics and an increased risk of hypoglycemia Details Hydroxychloroquine Goserelin Implant Zoladex Increased risk of QT interval prolongation Details Hydroxychloroquine Granisetron Transdermal Patch Sancuso Increased risk of QT interval prolongation Details Hydroxychloroquine Granisetron Injection Granisol Increased risk of QT interval prolongation Details Hydroxychloroquine Histrelin Implant Supprelin Increased risk of QT interval prolongation Details Hydroxychloroquine Hydromorphone Injection Dilaudid An increased risk of seizures Details Hydroxychloroquine Hydromorphone Rectal available generically An increased risk of seizures Details Hydroxychloroquine Acetazolamide Sodium Impaired antiepileptic activity Details Hydroxychloroquine Acetophenazine An increased risk of seizures Details Hydroxychloroquine Aclidinium Tudorza An increased risk of seizures Details Hydroxychloroquine Acrivastine An increased risk of seizures Details Hydroxychloroquine Adagrasib Krazati An increased risk of QT interval prolongation, torsade de pointes, polymorphic ventricular tachycardia, other serious arrhythmias Details Hydroxychloroquine Albiglutide Enhanced hypoglycemic effect of antidiabetics and an increased risk of hypoglycemia Details Hydroxychloroquine Alcaftadine An increased risk of seizures Details Hydroxychloroquine Alfentanil An increased risk of seizures Details Hydroxychloroquine Aluminum Carbonate, Basic Reduced hydroxychloroquine exposure Details Hydroxychloroquine Aluminum Hydroxide AlternaGEL® Reduced hydroxychloroquine exposure Details Hydroxychloroquine Aluminum Phosphate Reduced hydroxychloroquine exposure Details Hydroxychloroquine Ambenonium An increased risk of seizures Details Hydroxychloroquine Amdinocillin An increased risk of seizures Details Hydroxychloroquine Amineptine An increased risk of seizures Details Hydroxychloroquine Aminophylline Aminophyllin® Tablets An increased risk of seizures Details Hydroxychloroquine Amiodarone Nexterone An increased risk of QT interval prolongation and torsade de pointes Details Hydroxychloroquine Amisulpride Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Hydroxychloroquine Amitriptylinoxide An increased risk of seizures Details Hydroxychloroquine Amoxapine An increased risk of seizures Details Hydroxychloroquine Amphotericin B An increased risk of seizures Details Hydroxychloroquine Anisotropine An increased risk of seizures Details Hydroxychloroquine Antazoline An increased risk of seizures Details Hydroxychloroquine Apomorphine Apokyn Increased risk of QT interval prolongation Details Hydroxychloroquine Aripiprazole Abilify Increased risk of QT interval prolongation Details Hydroxychloroquine Artemether An increased risk of QT interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.