Hydroxychloroquine

631 interactions 1 explained in plain English 236 cited references

Also sold as: Plaquenil Plaquenil® Sovuna

About Hydroxychloroquine

Hydroxychloroquine is an antimalarial and antirheumatic drug used to prevent and treat malaria, lupus, and rheumatoid arthritis. Read the full Hydroxychloroquine drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Bepridil Ziprasidone Mesoridazine Levoketoconazole Cisapride Aurothioglucose

13 Contraindicated 616 Major 2 Moderate

All (631) Contraindicated (13) Major (616) Moderate (2)

Major

Hydroxychloroquine Asenapine Saphris Increased risk of QT interval prolongation Details Hydroxychloroquine Astemizole An increased risk of seizures and an increased risk of QT interval prolongation Details Hydroxychloroquine Atazanavir Reyataz Increased risk of QT interval prolongation Details Hydroxychloroquine Atropine Atropen An increased risk of seizures Details Hydroxychloroquine Azatadine An increased risk of seizures Details Hydroxychloroquine Azelastine An increased risk of seizures Details Hydroxychloroquine Azlocillin An increased risk of seizures Details Hydroxychloroquine Aztreonam An increased risk of seizures Details Hydroxychloroquine Bacampicillin An increased risk of seizures Details Hydroxychloroquine Baclofen Fleqsuvy An increased risk of seizures Details Hydroxychloroquine Balofloxacin An increased risk of seizures Details Hydroxychloroquine Belladonna Alkaloids An increased risk of seizures Details Hydroxychloroquine Benperidol An increased risk of seizures Details Hydroxychloroquine Benzhydrocodone An increased risk of seizures Details Hydroxychloroquine Bepotastine An increased risk of seizures Details Hydroxychloroquine Besifloxacin An increased risk of seizures Details Hydroxychloroquine Bornaprine An increased risk of seizures Details Hydroxychloroquine Bromodiphenhydramine An increased risk of seizures Details Hydroxychloroquine Bromperidol An increased risk of seizures Details Hydroxychloroquine Brompheniramine Respa-BR An increased risk of seizures Details Hydroxychloroquine Buclizine An increased risk of seizures Details Hydroxychloroquine Bupivacaine Exparel An increased risk of seizures Details Hydroxychloroquine Bupropion Aplenzin Increased risk of seizures Details Hydroxychloroquine Buserelin Increased risk of QT interval prolongation Details Hydroxychloroquine Buspirone Bucapsol An increased risk of seizures Details Hydroxychloroquine Busulfan Busulfex An increased risk of seizures Details Hydroxychloroquine Butorphanol Butorphic An increased risk of seizures Details Hydroxychloroquine Butriptyline An increased risk of seizures Details Hydroxychloroquine Butylscopolamine An increased risk of seizures Details Hydroxychloroquine Calcium Carbonate Alka-Mints Reduced hydroxychloroquine exposure Details Hydroxychloroquine Calcium Silicate Reduced hydroxychloroquine exposure Details Hydroxychloroquine Cannabidiol Epidiolex Impaired antiepileptic activity Details Hydroxychloroquine Carbamazepine Carbatrol Reduced carBAMazepine activity and an increased risk of seizures Details Hydroxychloroquine Carbenicillin An increased risk of seizures Details Hydroxychloroquine Carbinoxamine Carbzah An increased risk of seizures Details Hydroxychloroquine Cenobamate Xcopri Impaired antiepileptic activity Details Hydroxychloroquine Ceritinib Zykadia An increased risk of QT interval prolongation Details Hydroxychloroquine Chlorotrianisene An increased risk of seizures Details Hydroxychloroquine Chlorpheniramine An increased risk of seizures Details Hydroxychloroquine Chlorphenoxamine An increased risk of seizures Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.