Hydroxychloroquine

631 interactions 1 explained in plain English 236 cited references

Also sold as: Plaquenil Plaquenil® Sovuna

About Hydroxychloroquine

Hydroxychloroquine is an antimalarial and antirheumatic drug used to prevent and treat malaria, lupus, and rheumatoid arthritis. Read the full Hydroxychloroquine drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Bepridil Ziprasidone Mesoridazine Levoketoconazole Cisapride Aurothioglucose

13 Contraindicated 616 Major 2 Moderate

All (631) Contraindicated (13) Major (616) Moderate (2)

Major

Hydroxychloroquine Dexchlorpheniramine An increased risk of seizures Details Hydroxychloroquine Dexmedetomidine Dexased Increased risk of cardiac arrhythmias Details Hydroxychloroquine Dextroamphetamine Dexedrine An increased risk of seizures, increased dextroamphetamine or lisdexamfetamine (prodrug of dextroamphetamine) exposure and an incr... Details Hydroxychloroquine Diazepam Diastat Impaired antiepileptic activity Details Hydroxychloroquine Dibenzepin An increased risk of seizures Details Hydroxychloroquine Dicloxacillin An increased risk of seizures Details Hydroxychloroquine Dicyclomine Bentyl An increased risk of seizures Details Hydroxychloroquine Dienestrol An increased risk of seizures Details Hydroxychloroquine Diethylstilbestrol An increased risk of seizures Details Hydroxychloroquine Difenoxin An increased risk of seizures Details Hydroxychloroquine Dihydroartemisinin An increased risk of seizures Details Hydroxychloroquine Dihydroxyaluminum Aminoacetate Reduced hydroxychloroquine exposure Details Hydroxychloroquine Dihydroxyaluminum Sodium Carbonate Reduced hydroxychloroquine exposure Details Hydroxychloroquine Dimenhydrinate Airmit An increased risk of seizures Details Hydroxychloroquine Dimethindene An increased risk of seizures Details Hydroxychloroquine Diphenhydramine Banophen An increased risk of seizures Details Hydroxychloroquine Diphenoxylate An increased risk of seizures Details Hydroxychloroquine Diphenylpyraline An increased risk of seizures Details Hydroxychloroquine Distigmine An increased risk of seizures Details Hydroxychloroquine Divalproex Sodium Impaired antiepileptic activity Details Hydroxychloroquine Dixyrazine An increased risk of seizures Details Hydroxychloroquine Domperidone Increased risk of QT interval prolongation Details Hydroxychloroquine Donepezil Adlarity Increased risk of QT-interval prolongation and torsade de pointes Details Hydroxychloroquine Dordaviprone An increased risk of QT interval prolongation Details Hydroxychloroquine Dothiepin An increased risk of seizures Details Hydroxychloroquine Doxepin Prudoxin Increased risk of QT interval prolongation Details Hydroxychloroquine Doxofylline An increased risk of seizures Details Hydroxychloroquine Doxylamine Aldex AN An increased risk of seizures Details Hydroxychloroquine Droperidol An increased risk of seizures and an increased risk of QT interval prolongation Details Hydroxychloroquine Dulaglutide Trulicity Enhanced hypoglycemic effect of antidiabetics and an increased risk of hypoglycemia Details Hydroxychloroquine Ebastine An increased risk of seizures and an increased risk of QT interval prolongation Details Hydroxychloroquine Echothiophate An increased risk of seizures Details Hydroxychloroquine Efavirenz An increased risk of QT interval prolongation Details Hydroxychloroquine Emedastine An increased risk of seizures Details Hydroxychloroquine Enflurane An increased risk of seizures Details Hydroxychloroquine Enoxacin An increased risk of seizures Details Hydroxychloroquine Epinastine An increased risk of seizures Details Hydroxychloroquine Eribulin Halaven Increased risk of QT interval prolongation Details Hydroxychloroquine Erythromycin Erythrocin Stearate Increased risk of QT interval prolongation Details Hydroxychloroquine Escitalopram Lexapro An increased risk of seizures and an increased risk of QT interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.