Hydroxychloroquine

631 interactions 1 explained in plain English 236 cited references

Also sold as: Plaquenil Plaquenil® Sovuna

About Hydroxychloroquine

Hydroxychloroquine is an antimalarial and antirheumatic drug used to prevent and treat malaria, lupus, and rheumatoid arthritis. Read the full Hydroxychloroquine drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Bepridil Ziprasidone Mesoridazine Levoketoconazole Cisapride Aurothioglucose

13 Contraindicated 616 Major 2 Moderate

All (631) Contraindicated (13) Major (616) Moderate (2)

Major

Hydroxychloroquine Halofantrine An increased risk of seizures and an increased risk of QT interval prolongation Details Hydroxychloroquine Haloperidol Increased haloperidol exposure, an increased risk of haloperidol-related adverse events and increased risk of QT interval prolonga... Details Hydroxychloroquine Hetacillin An increased risk of seizures Details Hydroxychloroquine Histrelin Supprelin Increased risk of QT interval prolongation Details Hydroxychloroquine Homatropine Homatropaire An increased risk of seizures Details Hydroxychloroquine Hydrocodone Hysingla An increased risk of seizures Details Hydroxychloroquine Hydromorphone Dilaudid An increased risk of seizures Details Hydroxychloroquine Hydroquinidine Increased risk of QT interval prolongation Details Hydroxychloroquine Hydroxyamphetamine An increased risk of seizures Details Hydroxychloroquine Hydroxyzine An increased risk of seizures and an increased risk of QT interval prolongation Details Hydroxychloroquine Hyoscyamine Atropen An increased risk of seizures Details Hydroxychloroquine Ibutilide Corvert Increased risk of QT interval prolongation Details Hydroxychloroquine Ifosfamide Ifex An increased risk of seizures Details Hydroxychloroquine Iloperidone Fanapt Increased risk of QT interval prolongation Details Hydroxychloroquine Imipenem An increased risk of seizures Details Hydroxychloroquine Imipramine Increased risk of QT interval prolongation Details Hydroxychloroquine Indalpine An increased risk of seizures Details Hydroxychloroquine Inotuzumab Ozogamicin Besponsa Increased risk of QT interval prolongation Details Hydroxychloroquine Insulin Afrezza Enhanced hypoglycemic effect of antidiabetics and an increased risk of hypoglycemia Details Hydroxychloroquine Insulin Aspart, Recombinant Fiasp Enhanced hypoglycemic effect of antidiabetics and an increased risk of hypoglycemia Details Hydroxychloroquine Insulin Bovine Enhanced hypoglycemic effect of antidiabetics and an increased risk of hypoglycemia Details Hydroxychloroquine Insulin Degludec Tresiba Enhanced hypoglycemic effect of antidiabetics and an increased risk of hypoglycemia Details Hydroxychloroquine Insulin Detemir Levemir Enhanced hypoglycemic effect of antidiabetics and an increased risk of hypoglycemia Details Hydroxychloroquine Insulin Glulisine Apidra Enhanced hypoglycemic effect of antidiabetics and an increased risk of hypoglycemia Details Hydroxychloroquine Insulin Lispro, Recombinant Admelog Enhanced hypoglycemic effect of antidiabetics and an increased risk of hypoglycemia Details Hydroxychloroquine Iprindole An increased risk of seizures Details Hydroxychloroquine Isoflurane Fluriso An increased risk of seizures and an increased risk of QT interval prolongation with rare instances of torsade de pointes Details Hydroxychloroquine Isoflurophate An increased risk of seizures Details Hydroxychloroquine Isoniazid An increased risk of seizures Details Hydroxychloroquine Isopropamide An increased risk of seizures Details Hydroxychloroquine Itraconazole Sporanox Increased risk of QT interval prolongation Details Hydroxychloroquine Ivabradine Corlanor Increased risk of QT interval prolongation Details Hydroxychloroquine Ivosidenib Tibsovo An increased risk of QT interval prolongation Details Hydroxychloroquine Kaolin Pet Pectillin Reduced hydroxychloroquine exposure Details Hydroxychloroquine Ketamine An increased risk of seizures Details Hydroxychloroquine Ketoconazole Extina Increased risk of QT interval prolongation Details Hydroxychloroquine Ketotifen Alaway An increased risk of seizures Details Hydroxychloroquine Lacosamide Motpoly Impaired antiepileptic activity Details Hydroxychloroquine Lamotrigine Lamictal Impaired antiepileptic activity Details Hydroxychloroquine Lapatinib Tykerb Increased risk of QT interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.