Hydroxytryptophan

18 interactions 4 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Linezolid Injection Lithium Carbonate Granisetron Injection Hydromorphone Injection Hydromorphone Rectal Nalbuphine Injection
1 Contraindicated 17 Major
All (18) Contraindicated (1) Major (17)

Major

Hydroxytryptophan Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of serotonin syndrome Details Hydroxytryptophan Amitriptyline Elavil Explained Increased risk of serotonin syndrome (hypertension, tachycardia, hyperthermia, myoclonus, mental status changes) Details Hydroxytryptophan Sertraline Explained An increased risk of serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Hydroxytryptophan Buprenorphine Belbuca Explained An increased risk of serotonin syndrome Details Hydroxytryptophan Butorphanol Injection Butorphic Increased risk of serotonin syndrome Details Hydroxytryptophan Butorphanol Nasal Spray Stadol® NS Increased risk of serotonin syndrome Details Hydroxytryptophan Dolasetron Anzemet Increased risk of serotonin syndrome Details Hydroxytryptophan Dolasetron Injection Anzemet Increased risk of serotonin syndrome Details Hydroxytryptophan Fentanyl Transdermal Patch Duragesic® Increased risk of serotonin syndrome Details Hydroxytryptophan Granisetron Transdermal Patch Sancuso Increased risk of serotonin syndrome Details Hydroxytryptophan Granisetron Injection Granisol Increased risk of serotonin syndrome Details Hydroxytryptophan Hydromorphone Injection Dilaudid Increased risk of serotonin syndrome Details Hydroxytryptophan Hydromorphone Rectal available generically Increased risk of serotonin syndrome Details Hydroxytryptophan Lithium Carbonate Lithobid Increased risk of serotonin syndrome Details Hydroxytryptophan Morphine Injection Astramorph® PF Increased risk of serotonin syndrome Details Hydroxytryptophan Nalbuphine Injection Nubain® Increased risk of serotonin syndrome Details Hydroxytryptophan Palonosetron Injection Aloxi® An increased risk of serotonin syndrome Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.