Hyoscyamine

12 interactions 3 explained in plain English
Also sold as: Atropen Isopto Atropine
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Acetaminophen And Codeine Buprenorphine Fentanyl Transdermal Patch Glucagon Injection Glucagon Injection / Solution Glucagon Nasal Powder
11 Major 1 Moderate
All (12) Major (11) Moderate (1)

Major

Hyoscyamine Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of paralytic ileus Details Hyoscyamine Buprenorphine Belbuca Explained An increased risk of paralytic ileus Details Hyoscyamine Fentanyl Transdermal Patch Duragesic® Increased risk of urinary retention and/or severe constipation, which may lead to paralytic ileus Details Hyoscyamine Glucagon Injection Baqsimi Increased risk of gastrointestinal side effects Details Hyoscyamine Glucagon Injection / Solution Baqsimi Increased risk of gastrointestinal side effects Details Hyoscyamine Glucagon Nasal Powder Baqsimi Increased risk of gastrointestinal side effects Details Hyoscyamine Glycopyrronium Topical Cuvposa® An increased risk of anticholinergic side effects Details Hyoscyamine Hydromorphone Injection Dilaudid Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Hyoscyamine Hydromorphone Rectal available generically Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Hyoscyamine Hydroxychloroquine Plaquenil An increased risk of seizures Details Hyoscyamine Morphine Injection Astramorph® PF Increased risk of urinary retention, severe constipation, and paralytic ileus Details

Moderate

Hyoscyamine Trospium / Xanomeline Cobenfy Explained An increased risk of anticholinergic adverse reactions (eg, dry mouth, constipation) Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.