Ifosfamide Injection

98 interactions 796 cited references

Also sold as: Ifex Ifex®

About Ifosfamide Injection

Ifosfamide is used in combination with other medications to treat cancer of the testicles that has not improved or that has worsened after treatment with other medications or radiation therapy. Ifosfamide is in a class of medications called alkylating agents. It works by slowing or stopping the growth of cancer cells i… Read the full Ifosfamide Injection drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Dengue Tetravalent Vaccine, Live Ensitrelvir Measles Virus Vaccine, Live Mumps Virus Vaccine, Live Rubella Virus Vaccine, Live Smallpox Monkeypox Vaccine

10 Contraindicated 79 Major 9 Moderate

All (98) Contraindicated (10) Major (79) Moderate (9)

Contraindicated

Ifosfamide Injection Bacillus Of Calmette And Guerin Vaccine, Live An increased risk of infection by the live vaccine Details Ifosfamide Injection Dengue Tetravalent Vaccine, Live An increased risk of infection by the live vaccine Details Ifosfamide Injection Ensitrelvir Increased CYP3A substrates exposure and an increased risk of CYP3A substrates-related adverse effects Details Ifosfamide Injection Measles Virus Vaccine, Live An increased risk of infection by the live vaccine Details Ifosfamide Injection Mumps Virus Vaccine, Live An increased risk of infection by the live vaccine Details Ifosfamide Injection Rubella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Ifosfamide Injection Smallpox Monkeypox Vaccine An increased risk of infection by the live vaccine Details Ifosfamide Injection Typhoid Vaccine Typhim VI® An increased risk of infection by the live vaccine Details Ifosfamide Injection Varicella Virus Vaccine, Live An increased risk of infection by the live vaccine Details Ifosfamide Injection Yellow Fever Vaccine Stamaril An increased risk of infection by the live vaccine Details

Major

Ifosfamide Injection Abametapir Increased exposure of CYP3A4 substrate Details Ifosfamide Injection Abiraterone Acetate Abirtega Decreased ifosfamide effectiveness Details Ifosfamide Injection Abiraterone Acetate, Micronized Abirtega Decreased ifosfamide effectiveness Details Ifosfamide Injection Adenovirus Vaccine Type 4, Live An increased risk of infection by the live vaccine Details Ifosfamide Injection Adenovirus Vaccine Type 7, Live An increased risk of infection by the live vaccine Details Ifosfamide Injection Amprenavir Decreased ifosfamide effectiveness Details Ifosfamide Injection Apalutamide Erleada Reduced CYP3A4 substrate exposure Details Ifosfamide Injection Aprepitant Aponvie Increased chemotherapeutic agent exposure Details Ifosfamide Injection Articaine An increased risk of methemoglobinemia Details Ifosfamide Injection Atazanavir Reyataz Decreased ifosfamide effectiveness Details Ifosfamide Injection Avacopan Tavneos Increased CYP3A4 substrate exposure Details Ifosfamide Injection Boceprevir Decreased ifosfamide effectiveness Details Ifosfamide Injection Bupropion Aplenzin Increased risk of seizures Details Ifosfamide Injection Cannabidiol Epidiolex Altered (increased or reduced) CYP2B6 substrates exposure Details Ifosfamide Injection Carbamazepine Carbatrol Reduced ifosfamide exposure, reduced efficacy of ifosfamide and an increased neurotoxic and nephrotoxic effects Details Ifosfamide Injection Ceritinib Zykadia Decreased ifosfamide effectiveness Details Ifosfamide Injection Cholera Vaccine Ipol An increased risk of infection by the live vaccine Details Ifosfamide Injection Ciprofloxacin Decreased ifosfamide effectiveness Details Ifosfamide Injection Clarithromycin Biaxin Decreased ifosfamide effectiveness Details Ifosfamide Injection Clomipramine Anafranil Increased risk of seizures Details Ifosfamide Injection Cobicistat Tybost Decreased ifosfamide effectiveness Details Ifosfamide Injection Conivaptan Vaprisol Decreased ifosfamide effectiveness Details Ifosfamide Injection Crizotinib Xalkori Decreased ifosfamide effectiveness Details Ifosfamide Injection Darunavir Decreased ifosfamide effectiveness Details Ifosfamide Injection Delavirdine Rescriptor® Decreased ifosfamide effectiveness Details Ifosfamide Injection Diltiazem Cardizem Decreased ifosfamide effectiveness Details Ifosfamide Injection Dronedarone Multaq Decreased ifosfamide effectiveness Details Ifosfamide Injection Ebola Zaire Vaccine, Live An increased risk of infection by the live vaccine Details Ifosfamide Injection Efavirenz Increased neurotoxic and nephrotoxic effects Details Ifosfamide Injection Erythromycin Erythrocin Stearate Altered ifosfamide exposure, an increased risk of ifosfamide-related adverse effects and reduced efficacy of ifosfamide Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.