Iloperidone

69 interactions 4 explained in plain English
Also sold as: Fanapt Fanapt®
About Iloperidone

Iloperidone is an atypical antipsychotic used to treat symptoms of schizophrenia, including disturbed thinking and emotional problems. Read the full Iloperidone drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Metoclopramide Nasal Spray Metoclopramide Injection Ketoconazole Topical Moxifloxacin Injection Olodaterol Oral Inhalation Oxaliplatin Injection
3 Contraindicated 65 Major 1 Moderate
All (69) Contraindicated (3) Major (65) Moderate (1)

Major

Iloperidone Histrelin Implant Supprelin Increased risk of QT interval prolongation Details Iloperidone Hydroxychloroquine Plaquenil Increased risk of QT interval prolongation Details Iloperidone Inotuzumab Ozogamicin Injection Besponsa Increased risk of QT interval prolongation Details Iloperidone Ivabradine Corlanor Increased risk of QT prolongation Details Iloperidone Lefamulin Xenleta Increased risk of QT interval prolongation Details Iloperidone Lenvatinib Lenvima Increased risk of QT-interval prolongation Details Iloperidone Levofloxacin Levaquin Increased risk of QT interval prolongation Details Iloperidone Levofloxacin Injection Levaquin Increased risk of QT interval prolongation Details Iloperidone Loperamide Diamode An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Iloperidone Mefloquine Lariam® Increased risk of QT interval prolongation and torsade de pointes Details Iloperidone Metronidazole Flagyl An increased risk of QT interval prolongation Details Iloperidone Metronidazole Injection Flagyl An increased risk of QT interval prolongation Details Iloperidone Metronidazole Topical MetroCream® An increased risk of QT interval prolongation Details Iloperidone Metronidazole Vaginal MetroGel® Vaginal An increased risk of QT interval prolongation Details Iloperidone Moxifloxacin Avelox Increased risk of QT interval prolongation Details Iloperidone Moxifloxacin Injection Avelox Increased risk of QT interval prolongation Details Iloperidone Moxifloxacin Ophthalmic Moxeza® Increased risk of QT interval prolongation Details Iloperidone Nafarelin Nasal Spray Synarel An increased risk of QT interval prolongation Details Iloperidone Octreotide Bynfezia An increased risk of QT interval prolongation and an increased risk of cardiac arrhythmia Details Iloperidone Octreotide Injection Bynfezia An increased risk of QT interval prolongation and an increased risk of cardiac arrhythmia Details Iloperidone Ofloxacin Floxin® An increased risk of QT interval prolongation Details Iloperidone Ofloxacin Ophthalmic Ocuflox An increased risk of QT interval prolongation Details Iloperidone Ofloxacin Otic Floxin® Otic An increased risk of QT interval prolongation Details Iloperidone Olodaterol Oral Inhalation Striverdi An increased risk of QT interval prolongation and an increased risk of ventricular arrhythmias Details Iloperidone Oxaliplatin Injection Eloxatin® Increased risk of QT-interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.