Iloperidone

69 interactions 4 explained in plain English

Also sold as: Fanapt Fanapt®

About Iloperidone

Iloperidone is an atypical antipsychotic used to treat symptoms of schizophrenia, including disturbed thinking and emotional problems. Read the full Iloperidone drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Metoclopramide Nasal Spray Metoclopramide Injection Ketoconazole Topical Moxifloxacin Injection Olodaterol Oral Inhalation Oxaliplatin Injection

3 Contraindicated 65 Major 1 Moderate

All (69) Contraindicated (3) Major (65) Moderate (1)

Contraindicated

Iloperidone Ketoconazole Topical Extina® Foam Increased iloperidone exposure and an increased risk of QT interval prolongation Details Iloperidone Metoclopramide Injection Gimoti An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome Details Iloperidone Metoclopramide Nasal Spray Gimoti An increased risk of extrapyramidal reactions and neuroleptic malignant syndrome Details

Major

Iloperidone Amitriptyline Elavil Explained An increased risk of QT interval prolongation Details Iloperidone Sertraline Explained Increased risk of QT interval prolongation and an increased CYP2D6 substrate exposure Details Iloperidone Buprenorphine Belbuca Explained An increased risk of QT interval prolongation Details Iloperidone Relugolix Orgovyx Explained Increased risk of QT interval prolongation Details Iloperidone Amisulpride Injection Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Iloperidone Arsenic Trioxide Trisenox Increased risk of QT interval prolongation and torsade de pointes Details Iloperidone Aripiprazole Injection Abilify An increased risk of QT interval prolongation Details Iloperidone Arsenic Trioxide Injection Trisenox Increased risk of QT interval prolongation and torsade de pointes Details Iloperidone Asenapine Transdermal Patch Secuado Increased risk of QT interval prolongation and an increased risk of torsade de pointes Details Iloperidone Azithromycin AzaSite An increased risk of cardiotoxicity (QT interval prolongation, torsades de pointes, cardiac arrest) Details Iloperidone Cabergoline Dostinex® Reduced efficacy of cabergoline and reduced efficacy of dopamine-2 receptors Details Iloperidone Abiraterone Abirtega Increased CYP2D6 substrate exposure and an increased risk of CYP2D6 substrate-related adverse effects Details Iloperidone Alfuzosin UroXatral An increased risk of QT interval prolongation and increased risk of symptomatic hypotension Details Iloperidone Anagrelide Agrylin Increased risk of QT interval prolongation Details Iloperidone Bedaquiline Sirturo Increased risk of QT interval prolongation Details Iloperidone Chloroquine Aralen® An increased risk of QT interval prolongation Details Iloperidone Dasatinib Phyrago An increased risk of QT interval prolongation Details Iloperidone Degarelix Injection Firmagon Increased risk of QT interval prolongation Details Iloperidone Deutetrabenazine Austedo An increased risk of QT interval prolongation Details Iloperidone Disopyramide Norpace An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Iloperidone Dofetilide Tikosyn An increased risk of QT interval prolongation Details Iloperidone Dolasetron Anzemet An increased risk of QT interval prolongation Details Iloperidone Dolasetron Injection Anzemet An increased risk of QT interval prolongation Details Iloperidone Doxazosin Cardura Increased risk of symptomatic hypotension Details Iloperidone Encorafenib Braftovi Increased risk of QT interval prolongation Details Iloperidone Entrectinib Rozlytrek An increased risk of QT interval prolongation Details Iloperidone Eribulin Injection Halaven An increased risk of QT interval prolongation Details Iloperidone Famotidine Calmicid An increased risk of QT interval prolongation Details Iloperidone Famotidine Injection Calmicid An increased risk of QT interval prolongation Details Iloperidone Felbamate Felbatol An increased risk of QT interval prolongation Details Iloperidone Flecainide Tambocor® An increased risk of QT interval prolongation Details Iloperidone Foscarnet Injection Foscavir Increased risk of QT interval prolongation Details Iloperidone Fostemsavir Rukobia Increased risk of torsade de pointes Details Iloperidone Galantamine Razadyne An increased risk of QT interval prolongation Details Iloperidone Gatifloxacin Ophthalmic Zymar® Increased risk of QT interval prolongation and torsade de pointes Details Iloperidone Gemifloxacin Factive An increased risk of QT interval prolongation Details Iloperidone Glasdegib Daurismo Increased risk of QT interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.