Imipramine

111 interactions 6 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Imipramine Flurbiprofen Ophthalmic Ocufen An increased risk of bleeding Details Imipramine Foscarnet Injection Foscavir An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Imipramine Fostemsavir Rukobia Increased risk of torsade de pointes Details Imipramine Gatifloxacin Ophthalmic Zymar® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Imipramine Gemifloxacin Factive An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Imipramine Glasdegib Daurismo Increased risk of QT interval prolongation Details Imipramine Glucagon Injection Baqsimi Increased risk of gastrointestinal side effects Details Imipramine Glucagon Injection / Solution Baqsimi Increased risk of gastrointestinal side effects Details Imipramine Glucagon Nasal Powder Baqsimi Increased risk of gastrointestinal side effects Details Imipramine Glycopyrronium Topical Cuvposa® An increased risk of anticholinergic side effects Details Imipramine Goserelin Implant Zoladex Increased risk of QT interval prolongation Details Imipramine Granisetron Transdermal Patch Sancuso Increased risk of serotonin syndrome and QT-interval prolongation Details Imipramine Granisetron Injection Granisol Increased risk of serotonin syndrome and QT-interval prolongation Details Imipramine Histrelin Implant Supprelin Increased risk of QT interval prolongation Details Imipramine Hydromorphone Injection Dilaudid Increased risk of paralytic ileus and an increased risk of serotonin syndrome Details Imipramine Hydromorphone Rectal available generically Increased risk of paralytic ileus and an increased risk of serotonin syndrome Details Imipramine Hydroxychloroquine Plaquenil Increased risk of QT interval prolongation Details Imipramine Ibuprofen Addaprin An increased risk of bleeding Details Imipramine Inotuzumab Ozogamicin Injection Besponsa Increased risk of QT interval prolongation Details Imipramine Isradipine DynaCirc® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Imipramine Ivabradine Corlanor Increased risk of QT prolongation Details Imipramine Ketoconazole Topical Extina® Foam Increased risk of QT interval prolongation, reduced clearance and prolonged half-life of imipramine Details Imipramine Ketoprofen Actron® An increased risk of bleeding Details Imipramine Ketorolac Acular An increased risk of bleeding Details Imipramine Ketorolac Injection Acular An increased risk of bleeding Details Imipramine Ketorolac Nasal Spray Sprix An increased risk of bleeding Details Imipramine Ketorolac Ophthalmic Acular An increased risk of bleeding Details Imipramine Lefamulin Xenleta Increased risk of QT interval prolongation Details Imipramine Lenvatinib Lenvima Increased risk of QT-interval prolongation Details Imipramine Levofloxacin Levaquin Increased risk of QT interval prolongation Details Imipramine Levofloxacin Injection Levaquin Increased risk of QT interval prolongation Details Imipramine Lithium Carbonate Lithobid Increased risk of serotonin syndrome Details Imipramine Loperamide Diamode An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Imipramine Meclofenamate Meclodium® An increased risk of bleeding Details Imipramine Mefenamic Acid Ponstel® An increased risk of bleeding Details Imipramine Mefloquine Lariam® An increased risk of QT interval prolongation Details Imipramine Meloxicam Alloxate An increased risk of bleeding Details Imipramine Meloxicam Injection Alloxate An increased risk of bleeding Details Imipramine Methylphenidate Adhansia XR® Increased imipramine exposure Details Imipramine Methylphenidate Transdermal Patch Daytrana Increased imipramine exposure Details

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