Imipramine

111 interactions 6 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Imipramine Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of paralytic ileus; increased risk of serotonin syndrome Details Imipramine Amitriptyline Elavil Explained An increased risk of QT interval prolongation; an increased risk of serotonin syndrome (hypertension, hyperthermia, myoclonus, men... Details Imipramine Sertraline Explained Increased CYP2D6 substrate exposure, an increased risk of serotonin syndrome and an increased risk of QT interval prolongation Details Imipramine Albuterol Oral Inhalation Accuneb® Explained An increased risk of cardiovascular system effects Details Imipramine Buprenorphine Belbuca Explained An increased risk of QT interval prolongation, an increased risk of serotonin syndrome and an increased risk of paralytic ileus Details Imipramine Relugolix Orgovyx Explained Increased risk of QT interval prolongation Details Imipramine Amisulpride Injection Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Imipramine Arsenic Trioxide Trisenox An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Imipramine Aripiprazole Injection Abilify An increased risk of QT interval prolongation Details Imipramine Arsenic Trioxide Injection Trisenox An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Imipramine Asenapine Transdermal Patch Secuado Increased risk of QT interval prolongation Details Imipramine Aspirin Acuprin® An increased risk of bleeding Details Imipramine Aspirin Rectal Aspirin An increased risk of bleeding Details Imipramine Azithromycin AzaSite An increased risk of QT interval prolongation Details Imipramine Abiraterone Abirtega Increased CYP2D6 substrate exposure and an increased risk of CYP2D6 substrate-related adverse effects Details Imipramine Alfuzosin UroXatral An increased risk of QT interval prolongation Details Imipramine Anagrelide Agrylin Increased risk of QT interval prolongation Details Imipramine Bedaquiline Sirturo Increased risk of QT interval prolongation Details Imipramine Bromfenac Ophthalmic Bromday® An increased risk of bleeding Details Imipramine Chloroquine Aralen® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Imipramine Clonidine Transdermal Patch Catapres Reduced antihypertensive effects and may counteract the hypotensive effects of cloNIDine Details Imipramine Dacomitinib Vizimpro Increased exposure of the CYP2D6 substrate Details Imipramine Dasatinib Phyrago An increased risk of QT interval prolongation Details Imipramine Degarelix Injection Firmagon Increased risk of QT interval prolongation Details Imipramine Deutetrabenazine Austedo An increased risk of QT interval prolongation Details Imipramine Diclofenac Ophthalmic Voltaren® Eye Drops An increased risk of bleeding Details Imipramine Diclofenac Topical (Actinic Keratosis) Pennsaid An increased risk of bleeding Details Imipramine Diclofenac Topical (Arthritis Pain) Pennsaid® An increased risk of bleeding Details Imipramine Diclofenac Transdermal Patch Flector An increased risk of bleeding Details Imipramine Disopyramide Norpace An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Imipramine Dofetilide Tikosyn An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Imipramine Dolasetron Anzemet Increased risk of serotonin syndrome and QT-interval prolongation Details Imipramine Dolasetron Injection Anzemet Increased risk of serotonin syndrome and QT-interval prolongation Details Imipramine Encorafenib Braftovi Increased risk of QT interval prolongation Details Imipramine Entrectinib Rozlytrek An increased risk of QT interval prolongation Details Imipramine Etodolac Lodine An increased risk of bleeding Details Imipramine Fenoprofen Fenopron An increased risk of bleeding Details Imipramine Fentanyl Transdermal Patch Duragesic® Increased risk of paralytic ileus and an increased risk of serotonin syndrome Details Imipramine Flecainide Tambocor® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Imipramine Flurbiprofen Ansaid An increased risk of bleeding Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.