Imipramine

111 interactions 6 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Linezolid Injection Metoclopramide Injection Metoclopramide Nasal Spray Mefloquine Lefamulin Palonosetron Injection
3 Contraindicated 99 Major 5 Moderate 4 Minor
All (111) Contraindicated (3) Major (99) Moderate (5) Minor (4)

Major

Imipramine Metronidazole Flagyl An increased risk of QT interval prolongation Details Imipramine Metronidazole Injection Flagyl An increased risk of QT interval prolongation Details Imipramine Metronidazole Topical MetroCream® An increased risk of QT interval prolongation Details Imipramine Metronidazole Vaginal MetroGel® Vaginal An increased risk of QT interval prolongation Details Imipramine Morphine Injection Astramorph® PF Increased risk of urinary retention, severe constipation, paralytic ileus and an increased risk of serotonin syndrome Details Imipramine Moxifloxacin Avelox Increased risk of QT interval prolongation Details Imipramine Moxifloxacin Injection Avelox Increased risk of QT interval prolongation Details Imipramine Moxifloxacin Ophthalmic Moxeza® Increased risk of QT interval prolongation Details Imipramine Nabumetone Relafen An increased risk of bleeding Details Imipramine Nalbuphine Injection Nubain® Increased risk of serotonin syndrome and an increased risk of paralytic ileus Details Imipramine Naproxen Aleve An increased risk of bleeding Details Imipramine Octreotide Bynfezia An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Imipramine Octreotide Injection Bynfezia An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Imipramine Ofloxacin Floxin® An increased risk of QT interval prolongation Details Imipramine Ofloxacin Ophthalmic Ocuflox An increased risk of QT interval prolongation Details Imipramine Ofloxacin Otic Floxin® Otic An increased risk of QT interval prolongation Details Imipramine Olodaterol Oral Inhalation Striverdi An increased risk of QT interval prolongation, an increased risk of ventricular arrhythmias and potentiated cardiovascular effects Details Imipramine Oxaliplatin Injection Eloxatin® Increased risk of QT-interval prolongation Details Imipramine Palonosetron Injection Aloxi® An increased risk of serotonin syndrome Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.