Insulin Degludec (Rdna Origin) Injection

166 interactions 217 cited references

Also sold as: Ryzodeg® (as a combination product containing Insulin Degludec and Insulin Aspart) Tresiba Tresiba® Xultophy® (as a combination product containing Insulin Degludec and Liraglutide)

About Insulin Degludec (Rdna Origin) Injection

Insulin degludec is used to treat type 1 diabetes (condition in which the body does not produce insulin and therefore cannot control the amount of sugar in the blood). It is also used to treat people with type 2 diabetes (condition in which the body does not use insulin normally and, therefore, cannot control the amoun… Read the full Insulin Degludec (Rdna Origin) Injection drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Abiraterone Acetate Abiraterone Acetate, Micronized Acarbose Alogliptin Bromocriptine Canagliflozin

67 Major 99 Moderate

All (166) Major (67) Moderate (99)

Moderate

Insulin Degludec (Rdna Origin) Injection Isocarboxazid Marplan An increased risk of hypoglycemia Details Insulin Degludec (Rdna Origin) Injection Labetalol Normodyne® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Insulin Degludec (Rdna Origin) Injection Levobunolol Betagan Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Insulin Degludec (Rdna Origin) Injection Levothyroxine Ermeza Worsening of glycemic control Details Insulin Degludec (Rdna Origin) Injection Linezolid Zyvox An increased risk of hypoglycemia Details Insulin Degludec (Rdna Origin) Injection Lisinopril Prinivil An increased risk of hypoglycemia Details Insulin Degludec (Rdna Origin) Injection Lithium Hypoglycemia or hyperglycemia Details Insulin Degludec (Rdna Origin) Injection Lixisenatide An increased risk of hypoglycemia Details Insulin Degludec (Rdna Origin) Injection Losartan Arbli Increased risk of hypoglycemia Details Insulin Degludec (Rdna Origin) Injection Mesalamine Apriso Increased risk of hypoglycemia Details Insulin Degludec (Rdna Origin) Injection Methylene Blue Provayblue An increased risk of hypoglycemia Details Insulin Degludec (Rdna Origin) Injection Metipranolol Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Insulin Degludec (Rdna Origin) Injection Metoprolol Kapspargo Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Insulin Degludec (Rdna Origin) Injection Moexipril Univasc® An increased risk of hypoglycemia Details Insulin Degludec (Rdna Origin) Injection Nadolol Corgard Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Insulin Degludec (Rdna Origin) Injection Nebivolol Bystolic Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Insulin Degludec (Rdna Origin) Injection Olmesartan Benicar Increased risk of hypoglycemia Details Insulin Degludec (Rdna Origin) Injection Olmesartan Medoxomil Benicar Increased risk of hypoglycemia Details Insulin Degludec (Rdna Origin) Injection Olsalazine Dipentum Increased risk of hypoglycemia Details Insulin Degludec (Rdna Origin) Injection Oxprenolol Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Insulin Degludec (Rdna Origin) Injection Ozanimod An increased risk of hypoglycemia Details Insulin Degludec (Rdna Origin) Injection Paltusotine Palsonify An increased risk of hypoglycemia or hyperglycemia or diabetes mellitus Details Insulin Degludec (Rdna Origin) Injection Penbutolol Levatol® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Insulin Degludec (Rdna Origin) Injection Pentamidine NebuPent An increased risk of hypoglycemia or hyperglycemia Details Insulin Degludec (Rdna Origin) Injection Pentoxifylline Pentoxil® An increased risk of hypoglycemia Details Insulin Degludec (Rdna Origin) Injection Perindopril Aceon An increased risk of hypoglycemia Details Insulin Degludec (Rdna Origin) Injection Phenelzine Nardil An increased risk of hypoglycemia Details Insulin Degludec (Rdna Origin) Injection Pibrentasvir Altered glycemic control resulting in severe symptomatic hypoglycemia Details Insulin Degludec (Rdna Origin) Injection Pindolol Visken® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Insulin Degludec (Rdna Origin) Injection Practolol Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Insulin Degludec (Rdna Origin) Injection Procarbazine An increased risk of hypoglycemia Details Insulin Degludec (Rdna Origin) Injection Propoxyphene Increased risk of hypoglycemia Details Insulin Degludec (Rdna Origin) Injection Propranolol Hemangeol Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Insulin Degludec (Rdna Origin) Injection Quinapril Accupril An increased risk of hypoglycemia Details Insulin Degludec (Rdna Origin) Injection Ramipril Altace An increased risk of hypoglycemia Details Insulin Degludec (Rdna Origin) Injection Rasagiline Azilect An increased risk of hypoglycemia Details Insulin Degludec (Rdna Origin) Injection Safinamide Xadago An increased risk of hypoglycemia Details Insulin Degludec (Rdna Origin) Injection Salsalate Disalcid Increased risk of hypoglycemia Details Insulin Degludec (Rdna Origin) Injection Saxagliptin Onglyza Increased risk of hypoglycemia Details Insulin Degludec (Rdna Origin) Injection Selegiline Anipryl An increased risk of hypoglycemia Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.