Insulin Degludec (Rdna Origin) Injection

166 interactions 217 cited references

Also sold as: Ryzodeg® (as a combination product containing Insulin Degludec and Insulin Aspart) Tresiba Tresiba® Xultophy® (as a combination product containing Insulin Degludec and Liraglutide)

About Insulin Degludec (Rdna Origin) Injection

Insulin degludec is used to treat type 1 diabetes (condition in which the body does not produce insulin and therefore cannot control the amount of sugar in the blood). It is also used to treat people with type 2 diabetes (condition in which the body does not use insulin normally and, therefore, cannot control the amoun… Read the full Insulin Degludec (Rdna Origin) Injection drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Abiraterone Acetate Abiraterone Acetate, Micronized Acarbose Alogliptin Bromocriptine Canagliflozin

67 Major 99 Moderate

All (166) Major (67) Moderate (99)

Major

Insulin Degludec (Rdna Origin) Injection Abiraterone Acetate Abirtega An increased risk of severe hypoglycemia Details Insulin Degludec (Rdna Origin) Injection Abiraterone Acetate, Micronized Abirtega An increased risk of severe hypoglycemia Details Insulin Degludec (Rdna Origin) Injection Acarbose Prandase® An increased risk of hypoglycemia Details Insulin Degludec (Rdna Origin) Injection Alogliptin Nesina An increased risk of hypoglycemia Details Insulin Degludec (Rdna Origin) Injection Bromocriptine Cycloset An increased risk of hypoglycemia Details Insulin Degludec (Rdna Origin) Injection Canagliflozin Invokana An increased risk of hypoglycemia Details Insulin Degludec (Rdna Origin) Injection Chloroquine Aralen® Hypoglycemia Details Insulin Degludec (Rdna Origin) Injection Chlorothiazide Diuril An increased risk of hyperglycemia and an increased insulin requirement Details Insulin Degludec (Rdna Origin) Injection Chlorpropamide Diabinese® An increased risk of hypoglycemia Details Insulin Degludec (Rdna Origin) Injection Chlorthalidone Hemiclor An increased risk of hyperglycemia and an increased insulin requirement Details Insulin Degludec (Rdna Origin) Injection Ciprofloxacin Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Insulin Degludec (Rdna Origin) Injection Dapagliflozin Farxiga An increased risk of hypoglycemia Details Insulin Degludec (Rdna Origin) Injection Delafloxacin Baxdela Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Insulin Degludec (Rdna Origin) Injection Empagliflozin Glyxambi® (as a combination product containing Empagliflozin and Linagliptin) An increased risk of hypoglycemia Details Insulin Degludec (Rdna Origin) Injection Enoxacin Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Insulin Degludec (Rdna Origin) Injection Ertugliflozin Steglatro An increased risk of hypoglycemia Details Insulin Degludec (Rdna Origin) Injection Exenatide Bydureon Increased risk of hypoglycemia Details Insulin Degludec (Rdna Origin) Injection Furosemide Disal An increased risk of hyperglycemia and an increased insulin requirement Details Insulin Degludec (Rdna Origin) Injection Gatifloxacin Zymaxid Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Insulin Degludec (Rdna Origin) Injection Gemifloxacin Factive Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Insulin Degludec (Rdna Origin) Injection Glimepiride Amaryl An increased risk of hypoglycemia Details Insulin Degludec (Rdna Origin) Injection Glipizide Glucotrol An increased risk of hypoglycemia Details Insulin Degludec (Rdna Origin) Injection Glyburide DiaBeta® An increased risk of hypoglycemia Details Insulin Degludec (Rdna Origin) Injection Grepafloxacin Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Insulin Degludec (Rdna Origin) Injection Hydrochlorothiazide Inzirqo An increased risk of hyperglycemia and an increased insulin requirement Details Insulin Degludec (Rdna Origin) Injection Hydroflumethiazide An increased risk of hyperglycemia and an increased insulin requirement Details Insulin Degludec (Rdna Origin) Injection Hydroxychloroquine Plaquenil Enhanced hypoglycemic effect of antidiabetics and an increased risk of hypoglycemia Details Insulin Degludec (Rdna Origin) Injection Indapamide An increased risk of hyperglycemia and an increased insulin requirement Details Insulin Degludec (Rdna Origin) Injection Insulin Aspart, Recombinant Fiasp An increased risk of hypoglycemia Details Insulin Degludec (Rdna Origin) Injection Insulin Glargine, Recombinant Basaglar An increased risk of hypoglycemia Details Insulin Degludec (Rdna Origin) Injection Insulin Icodec-Abae Awiqli An increased risk of hypoglycemia Details Insulin Degludec (Rdna Origin) Injection Lanreotide Acetate An increased risk of hypoglycemia and impaired glucose regulation Details Insulin Degludec (Rdna Origin) Injection Levofloxacin Levaquin Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Insulin Degludec (Rdna Origin) Injection Linagliptin Tradjenta An increased risk of hypoglycemia Details Insulin Degludec (Rdna Origin) Injection Liraglutide Saxenda An increased risk of hypoglycemia Details Insulin Degludec (Rdna Origin) Injection Lomefloxacin Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Insulin Degludec (Rdna Origin) Injection Macimorelin False-positive or false-negative adult growth hormone deficiency diagnosis Details Insulin Degludec (Rdna Origin) Injection Metformin Fortamet® An increased risk of hypoglycemia Details Insulin Degludec (Rdna Origin) Injection Metoclopramide Risk of hyperglycemia Details Insulin Degludec (Rdna Origin) Injection Metolazone An increased risk of hyperglycemia and an increased insulin requirement Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.